Document 0810
 DOCN  M9460810
 TI    Adult T-cell leukemia-lymphoma: a clinico-pathologic study of twenty-six
       patients from Martinique.
 DT    9404
 AU    Plumelle Y; Pascaline N; Nguyen D; Panelatti G; Jouannelle A; Jouault H;
       Imbert M; Hematology Laboratory, Regional Medical Center, Fort de
       France,; Martinique.
 SO    Hematol Pathol. 1993;7(4):251-62. Unique Identifier : AIDSLINE
       MED/94156814
 AB    Twenty-six cases of adult T-cell leukemia/lymphoma (ATLL) were
       identified between 1983 and 1991 in Martinique (French West Indies).
       There were 14 men and 12 women, all of mixed racial descent and born in
       Martinique. Their ages ranged from 23 to 95 years. The main clinical and
       laboratory features at initial presentation were peripheral
       lymphadenopathy (22 cases), hepatomegaly (11 cases), splenomegaly (10
       cases), cutaneous lesions (12 cases), hypercalcemia (16 cases),
       refractory infection by Strongyloides stercoralis (12 cases), and
       pre-existing autoimmune disorders (4 cases). All patients had absolute
       lymphocytosis with circulating pleomorphic abnormal lymphocytes. The
       prognosis was poor, with most patients (20 cases) surviving for less
       than 6 months. Although the overall clinicopathologic features of ATLL
       in this series are similar to those described in previous reports, we
       observed three additional points of interest: a high association with
       Strongyloides infection, an increased incidence of tropical spastic
       paresis/HTLV-1 associated myelopathy (TSP/HAM) among the relatives of
       the patients (5 cases), and the presence of prior collagen vascular
       diseases.
 DE    Adult  Aged  Aged, 80 and over  Animal  Female  Human  HTLV-I
       Antibodies/BLOOD  Immunophenotyping  Leukemia-Lymphoma, T-Cell, Acute,
       HTLV-I-Associated/BLOOD/  *DIAGNOSIS/PATHOLOGY  Male  Martinique  Middle
       Age  Strongyloides stercoralis/ISOLATION & PURIF
       Strongyloidiasis/COMPLICATIONS  JOURNAL ARTICLE

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