Document 0816
 DOCN  M9460816
 TI    Immunoglobulin A (IgA), IgA1, and IgA2 antibodies to Candida albicans in
       whole and parotid saliva in human immunodeficiency virus infection and
       AIDS.
 DT    9404
 AU    Coogan MM; Sweet SP; Challacombe SJ; Centre for the Study of the Oral
       Manifestations of HIV Infection,; UMDS Guy's Hospital, London, United
       Kingdom.
 SO    Infect Immun. 1994 Mar;62(3):892-6. Unique Identifier : AIDSLINE
       MED/94156483
 AB    Human immunodeficiency virus (HIV)-infected individuals are predisposed
       to recurrent oral candidiasis, and, although it has been assumed that
       this is because of deficient mucosal immune responses, this has not been
       properly established. The present study aimed to compare the
       concentrations and secretion rates of immunoglobulin A (IgA) and IgA
       subclass antibodies to Candida albicans in whole and parotid saliva
       samples from HIV-infected patients, AIDS patients, and control subjects.
       Levels of IgA antibody to Candida species in whole saliva were higher in
       the HIV group than in the controls and were highest in the AIDS group (P
       < 0.05). In parotid saliva, the mean antibody levels were significantly
       greater in HIV-positive patients than in controls (P < 0.05) but fell to
       lower levels in the AIDS group. The secretion rates of Candida
       antibodies in parotid saliva were reduced in AIDS patients compared with
       HIV patients. The specific activities of the IgA antibodies and both
       subclasses were significantly higher in the HIV and AIDS patients than
       in the controls in both whole and parotid saliva (P < 0.05). Antibody
       levels were significantly correlated with the numbers of Candida
       organisms isolated from saliva (P < 0.05). These results suggest clear
       differences in salivary antibody profiles among HIV-infected. AIDS, and
       control subjects and are indicative of a response to antigenic challenge
       by infecting Candida species. No obvious defect in the mucosal immune
       response in the HIV or AIDS groups that might account for the increased
       prevalence of candidiasis was apparent.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Adult  Aged  Antibodies,
       Fungal/*ANALYSIS  AIDS-Related Opportunistic Infections/*IMMUNOLOGY
       Candida albicans/*IMMUNOLOGY  Candidiasis, Oral/*IMMUNOLOGY  Human
       IgA/*ANALYSIS/CLASSIFICATION  Male  Middle Age  Saliva/*MICROBIOLOGY
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).