Document 0817
 DOCN  M9460817
 TI    Restriction of T cell receptor variable region in lymph nodes of adult T
       cell leukemia/lymphoma.
 DT    9404
 AU    Ohshima K; Kikuchi M; Yoneda S; Kobari S; Sumiyosi Y; Takeshita M;
       Kimura N; Department of Pathology, School of Medicine, Fukuoka
       University,; Japan.
 SO    Hematol Oncol. 1993 May-Jun;11(3):147-54. Unique Identifier : AIDSLINE
       MED/94156332
 AB    Adult T cell leukemia/lymphoma (ATLL) is a mature T cell malignancy,
       especially derived from the CD4 positive T cell. To characterize the T
       cell, we examined the representation of T cell antigen receptor variable
       region, using the monoclonal antibodies [beta V 5 (a), beta V 5 (b),
       beta V 6 (a), beta V 8 (a), beta V 12 (a), alpha V 2 (a), alpha-beta V
       (a)]. Clinicopathologically we classified the lymph nodes of patients
       with ATLL into three states (1) human T cell leukemia virus type I
       (HTLV-I) associated lymphadenitis, reactive state; (2) incipient ATLL,
       early or pre-neoplastic state; and (3) ATLL, neoplastic state. The lymph
       nodes of all three states were composed of unvarying CD4 positive T
       cells. Most of the lymph nodes with ATLL consistently presented alpha V
       2 antigen, but no others. In HTLV-I associated lymphadenitis, only a few
       cells reacted for alpha V 2, as in non-specific lymphadenitis without
       ATLL features. One of three cases with incipient ATLL presented alpha V
       2. The selected expression of T cell antigen receptor V region might be
       associated with the presence of HTLV-I encoded superantigen, similar to
       human immunodeficiency virus (HIV).
 DE    Adult  Aged  Aged, 80 and over  Base Sequence  DNA, Viral/ANALYSIS
       Human  HTLV-I/GENETICS  Leukemia-Lymphoma, T-Cell, Acute,
       HTLV-I-Associated/GENETICS/  *IMMUNOLOGY/PATHOLOGY  Lymph
       Nodes/IMMUNOLOGY/*PATHOLOGY  Middle Age  Molecular Sequence Data
       Receptors, Antigen, T-Cell, alpha-beta/*ANALYSIS/GENETICS  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

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