Document 0820
 DOCN  M9460820
 TI    A prospective four-year follow-up of neuropsychological function in HIV
       seropositive and seronegative methadone-maintained patients.
 DT    9404
 AU    Silberstein CH; O'Dowd MA; Chartock P; Schoenbaum EE; Friedland G;
       Hartel D; McKegney FP; Department of Psychiatry, Albert Einstein College
       of Medicine,; Montefiore Medical Center, Bronx, NY 10467.
 SO    Gen Hosp Psychiatry. 1993 Nov;15(6):351-9. Unique Identifier : AIDSLINE
       MED/94156149
 AB    The evolution of central nervous system (CNS) impairments associated
       with human immunodeficiency virus (HIV) infection was assessed by a
       prospective, longitudinal study of patients in a methadone maintenance
       clinic. At a mean of 47 months after baseline testing, which included
       physical exams, HIV antibody testing and a neuropsychological (NP)
       screening battery, 121 subjects received a second NP assessment. Forty
       subjects (33%) who were seropositive at baseline showed statistically
       significant declines in NP function over the 4 years compared with 81
       seronegatives, on the Finger Tapping and Trail Making B tests. This
       relatively long-term follow-up suggests that subtle cognitive deficits
       develop over time and can be identified early, but their course is slow
       and appears generally to parallel that of non-CNS symptoms/signs of HIV
       infection.
 DE    Adult  Ambulatory Care  AIDS Dementia Complex/*DIAGNOSIS/PSYCHOLOGY
       Female  Follow-Up Studies  Human  *HIV Seronegativity  HIV
       Seropositivity/*DIAGNOSIS/PSYCHOLOGY  Longitudinal Studies  Male
       Methadone/*THERAPEUTIC USE  Narcotic
       Dependence/COMPLICATIONS/PSYCHOLOGY/*REHABILITATION  *Neuropsychological
       Tests  New York City  Prospective Studies  Substance Abuse,
       Intravenous/COMPLICATIONS/PSYCHOLOGY/  *REHABILITATION  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).