Document 0824
 DOCN  M9460824
 TI    Bronchoalveolar lavage cell analysis in measles viral pneumonia.
 DT    9404
 AU    Myou S; Fujimura M; Yasui M; Ueno T; Matsuda T; Dept of Internal
       Medicine, Asanogawa General Hospital, Kanazawa,; Japan.
 SO    Eur Respir J. 1993 Nov;6(10):1437-42. Unique Identifier : AIDSLINE
       MED/94156011
 AB    Although the immunological changes due to measles virus infection, such
       as suppression of delayed skin reactivity and increase in soluble CD8 in
       peripheral blood, have been demonstrated, the immunological changes in
       the lung during measles viral pneumonia (MVP) have not been reported.
       The aim of this study was to clarify the intrapulmonary immunological
       changes in MVP. We analysed cell differentials and lymphocyte surface
       antigens of bronchoalveolar lavage (BAL) cells, both in the acute and
       the convalescent phase of MVP by flow-cytometry, using CD4+, CD8+,
       CD8+CD11b+ and CD8+CD11b- monoclonal antibodies in five patients and six
       healthy control subjects. The absolute numbers of CD8+ and CD8+CD11b-
       cells were significantly greater both in the acute and the convalescent
       phase compared with those in controls. The percentages of CD8+ and
       CD8+CD11b- cells in the acute phase were significantly greater than
       those in controls and the convalescent phase. The CD4/CD8 ratios in the
       acute phase were significantly smaller than those in the convalescent
       phase and controls. In conclusion, the intrapulmonary immunological
       changes with an increase in CD8+ and CD8+CD11b- cells in BAL fluid of
       MVP are thought to be the primary reaction in measles virus-infected
       lungs.
 DE    Acute Disease  Adolescence  Adult  Bronchoalveolar Lavage
       Fluid/*CYTOLOGY/*IMMUNOLOGY  Convalescence  CD4-CD8 Ratio  Female  Human
       Lung/IMMUNOLOGY  Lymphocyte Subsets  Male  Measles/*IMMUNOLOGY
       Pneumonia, Viral/*IMMUNOLOGY  JOURNAL ARTICLE

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