Document 0827
 DOCN  M9460827
 TI    Pyrimethamine plus azithromycin for treatment of acute toxoplasmic
       encephalitis in patients with AIDS.
 DT    9404
 AU    Saba J; Morlat P; Raffi F; Hazebroucq V; Joly V; Leport C; Vilde JL;
       Service de Maladies Infectieuses et Tropicales, CHU Bichat-Claude;
       Bernard, Paris, France.
 SO    Eur J Clin Microbiol Infect Dis. 1993 Nov;12(11):853-6. Unique
       Identifier : AIDSLINE MED/94155915
 AB    A prospective study was conducted to evaluate azithromycin in
       combination with pyrimethamine for treatment of acute Toxoplasma
       encephalitis in patients with AIDS. Of the 14 patients given 75 mg
       pyrimethamine and 500 mg azithromycin daily for four weeks, eight were
       evaluable for clinical response. Five responded favorably, one had an
       intermediate response and two an unfavorable response. Of the nine
       patients evaluable for radiological response, six responded favorably,
       and three had an intermediate response. Eleven adverse events occurred
       in nine patients: rash (n = 5), abnormal liver function (n = 2),
       vomiting (n = 3) and hypoacousia (n = 1). This pilot study suggests that
       the combination of pyrimethamine and azithromycin may be further
       investigated and that the optimal dosage of azithromycin has yet to be
       determined.
 DE    Acute Disease  Adult  Azithromycin/ADMINISTRATION & DOSAGE/ADVERSE
       EFFECTS/*THERAPEUTIC  USE  AIDS-Related Opportunistic Infections/*DRUG
       THERAPY  Drug Administration Schedule  Drug Therapy, Combination
       Encephalitis/*DRUG THERAPY  Female  Human  Male  Middle Age  Pilot
       Projects  Prospective Studies  Pyrimethamine/ADMINISTRATION &
       DOSAGE/ADVERSE EFFECTS/  *THERAPEUTIC USE  Sulfadiazine/THERAPEUTIC USE
       Toxoplasmosis, Cerebral/*DRUG THERAPY  CLINICAL TRIAL  CLINICAL TRIAL,
       PHASE I  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).