Document 0869 DOCN M9460869 TI Long-term effects of early nutritional support with new enterotropic peptide-based formula vs. standard enteral formula in HIV-infected patients: randomized prospective trial [see comments] DT 9404 AU Chlebowski RT; Beall G; Grosvenor M; Lillington L; Weintraub N; Ambler C; Richards EW; Abbruzzese BC; McCamish MA; Cope FO; UCLA-Harbor Medical Center, Torrance. SO Nutrition. 1993 Nov-Dec;9(6):507-12. Unique Identifier : AIDSLINE MED/94154398 CM Comment in: Nutrition 1993 Nov-Dec;9(6):554-6 AB Despite association with adverse clinical outcome, human immunodeficiency virus (HIV)-associated malnutrition has been relatively refractory to conventional nutrition management. Consequently, a prospective randomized trial was conducted to evaluate a new peptide-based enteral formula (NEF) in contrast to a standard enteral formula (SEF) in patients with HIV infection. Eighty early-stage largely asymptomatic patients were randomized into a dietary regimen supplemented with either a ready-to-feed NEF (18.7% protein, 65.5% carbohydrate, 15.8% fat; 1.28 kcal/ml) or SEF (14% protein, 55% carbohydrate, 31% fat; 1.06 kcal/ml). Patients received 2-3 8-oz cans of the NEF or SEF supplement per day for 6 mo. Parameters evaluated at 0 (baseline), 3, and 6 mo included adherence, weight change, anthropometric measurements, serum biochemical indices, gastrointestinal symptoms, physical performance, and intercurrent health events (including hospitalizations). For the 56 evaluable patients, those supplemented with NEF maintained their body weight significantly (p = 0.04) better, had significantly (p = 0.03) more stable triceps skin-fold measurements, and had significantly (p = 0.04) lower blood urea nitrogen than patients consuming the SEF supplement. Consumption of the NEF supplement was also associated with significantly reduced hospitalizations during the 3- to 6-mo evaluation period (p = 0.02). The NEF supplement was well tolerated and did not result in untoward clinical effects. These data suggest that supplemental use of an NEF provides superior nutritional management compared with an SEF for patients with early-stage HIV infection. DE Adolescence Adult Analysis of Variance Blood Urea Nitrogen Body Weight Caloric Intake Comparative Study Creatinine/BLOOD Dietary Proteins/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE Enteral Nutrition Female Follow-Up Studies *Food, Formulated Hospitalization Human HIV Infections/COMPLICATIONS/*DIET THERAPY Male Middle Age Patient Compliance Prospective Studies Protein-Energy Malnutrition/ETIOLOGY/*PREVENTION & CONTROL Serum Albumin/ANALYSIS Skinfold Thickness CLINICAL TRIAL JOURNAL ARTICLE RANDOMIZED CONTROLLED TRIAL SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).