Document 0877
 DOCN  M9460877
 TI    The interaction of substituted 2-phenylquinoline intercalators with
       poly(A).poly(U): classical and threading intercalation modes with RNA.
 DT    9404
 AU    Zhao M; Janda L; Nguyen J; Strekowski L; Wilson WD; Department of
       Chemistry, Georgia State University, Atlanta 30303.
 SO    Biopolymers. 1994 Jan;34(1):61-73. Unique Identifier : AIDSLINE
       MED/94154168
 AB    The interaction of a series of 2-phenylquinoline derivatives with RNA
       was investigated by means of viscometric, pKa, spectroscopic, binding,
       Tm, and kinetic methods. Compounds 1, 2, and 3 have a piperazyl
       substituent at the para, meta, or ortho position, respectively, while 4
       has an unsubstituted phenyl ring. The pKa results suggest that 1 has
       three charges, 2 and 3 have more than two charges, and 4 has two charges
       at pH 6.2. Spectroscopic and Tm results indicate that 1 binds more
       strongly to RNA than 2-4. Kinetic and modeling results indicate that 1
       is a threading intercalator while 2 and 4 are classical intercalators.
       All experimental results indicate that 3, which has a large twist
       between the phenyl and quinoline rings, binds weakly with RNA.
 DE    Antiviral Agents/CHEMISTRY/PHARMACOLOGY  Binding Sites  HIV-1/DRUG
       EFFECTS  Intercalating Agents/*CHEMISTRY/PHARMACOLOGY  Kinetics  Poly
       A-U/*CHEMISTRY  Quinolines/CHEMISTRY/PHARMACOLOGY  RNA/*CHEMISTRY/DRUG
       EFFECTS  RNA, Viral/CHEMISTRY/DRUG EFFECTS  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).