Document 0884
 DOCN  M9460884
 TI    Fluconazole-resistant Candida albicans.
 DT    9404
 AU    Boken DJ; Swindells S; Rinaldi MG; Department of Internal Medicine,
       University of Nebraska Medical; Center, Omaha 68198-5400.
 SO    Clin Infect Dis. 1993 Dec;17(6):1018-21. Unique Identifier : AIDSLINE
       MED/94154100
 AB    Mucocutaneous candidiasis caused by Candida albicans is a common
       complication of human immunodeficiency virus (HIV) infection. Recent
       reports of isolation of resistant strains of C. albicans raise the
       specter of more widespread resistance, but limited series are available
       to analyze situations in which the likelihood of resistance is greatest.
       We present our experience with fluconazole-resistant candidiasis in
       patients with HIV infection obtained from retrospective chart review and
       by testing strains of C. albicans isolated during relapse for
       susceptibility to antifungal agents. The possible reasons for failure of
       antifungal therapy are discussed, as well the correlation between in
       vivo and in vitro data. Resistant candidiasis in patients with HIV
       disease is an emerging problem of considerable concern that merits
       further study.
 DE    Adult  Antifungal Agents/PHARMACOLOGY  AIDS-Related Opportunistic
       Infections/COMPLICATIONS/*DRUG THERAPY/  MICROBIOLOGY  Candida
       albicans/DRUG EFFECTS  Candidiasis, Chronic
       Mucocutaneous/COMPLICATIONS/*DRUG THERAPY/  MICROBIOLOGY  Case Report
       Drug Resistance, Microbial  Fluconazole/*THERAPEUTIC USE  Human  Male
       Microbial Sensitivity Tests  JOURNAL ARTICLE

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