Document 0965
 DOCN  M9460965
 TI    Viral vector for induction of CTL (Meeting abstract).
 DT    9406
 AU    Paoletti E; Virogenetics Corp., Rensselaer Technology Park, Troy, NY
 SO    Specific Immunotherapy of Cancer with Vaccines. January 21-24, 1993,
       Washington, DC, A34, 1993.. Unique Identifier : AIDSLINE ICDB/94698150
 AB    Two unique poxvirus vectors are available for expression of foreign
       genes. NYVAC is an attenuated strain of the Copenhagen vaccinia smallpox
       vaccine. Attenuation was effected by the precise deletion of 18 open
       reading frames associated with virulence or host range. NYVAC is safe by
       numerous tests including intracranial inoculation into newborn mice. No
       disseminated infection was observed in severely immunocompromised
       animals. ALVAC is an avipoxvirus, canary-pox. Avipoxviruses are
       restricted for productive viral replication to avian species and in
       mammals provide uniquely safe immunizing vehicles. Upon inoculation in
       mammalian species, including man, ALVAC elicits cellular, humoral and
       protective immunity. One of the features inherent within this vector
       approach is the intracellular synthesis of antigens which allows for the
       association of peptides with MHC-1. Cellular immune responses including
       specific induction of CD8+ CTL responses have been demonstrated with
       human immunodeficiency virus, cytomegalovirus and rabiesvirus proteins
       in laboratory animal model systems as well as in man. These vectors are
       also useful in the ex vivo expansion of CD8+ CTLs from HIV
       seropositives. The utility of these vectors for the expression of
       tumor-associated antigens in conjunction with specific cytokines is just
       now beginning to be evaluated.
 DE    Animal  Antibody Formation  *Genetic Vectors  HIV Infections/IMMUNOLOGY
       HIV Seropositivity/IMMUNOLOGY  Immunity, Cellular  *Immunotherapy  Mice
       Poxviridae/GENETICS/*IMMUNOLOGY  T-Lymphocytes, Cytotoxic/*IMMUNOLOGY
       Vaccinia Virus/*IMMUNOLOGY/PHYSIOLOGY  Virus Replication  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).