Document 0021 DOCN M9460021 TI Application and accuracy of molecular phylogenies. DT 9408 AU Hillis DM; Huelsenbeck JP; Cunningham CW; Department of Zoology, University of Texas, Austin 78712. SO Science. 1994 Apr 29;264(5159):671-7. Unique Identifier : AIDSLINE MED/94225204 AB Molecular investigations of evolutionary history are being used to study subjects as diverse as the epidemiology of acquired immune deficiency syndrome and the origin of life. These studies depend on accurate estimates of phylogeny. The performance of methods of phylogenetic analysis can be assessed by numerical simulation studies and by the experimental evolution of organisms in controlled laboratory situations. Both kinds of assessment indicate that existing methods are effective at estimating phylogenies over a wide range of evolutionary conditions, especially if information about substitution bias is used to provide differential weightings for character transformations. DE Bacteriophage T7/*GENETICS Computer Simulation Dentists Disease Transmission, Professional-to-Patient Evolution Female *Genome, Viral Human HIV/*GENETICS HIV Envelope Protein gp120/GENETICS HIV Infections/MICROBIOLOGY/TRANSMISSION Male Models, Biological *Phylogeny Probability Support, U.S. Gov't, Non-P.H.S. JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).