Document 0031
 DOCN  M9460031
 TI    Induction of feline acquired immune deficiency syndrome by feline
       leukemia virus: immuno- and neuroendocrine dysfunctions.
 DT    9408
 AU    Wang SW; Teng CS; Department of Anatomy, Physiological Sciences and
       Radiology,; College of Veterinary Medicine, North Carolina State
       University,; Raleight 27606.
 SO    Proc Soc Exp Biol Med. 1994 Apr;205(4):332-9. Unique Identifier :
       AIDSLINE MED/94224909
 AB    Young cats, when chronically infected with feline leukemia virus (FeLV),
       developed feline acquired immune deficiency syndrome (FAIDS). The
       syndrome was associated with a sequence of dysfunctions in the
       hypothalamic-pituitary-gonadal (HPG) and the immune system, manifested
       in the reduction of luteinizing hormone-releasing hormone (LHRH),
       follicle stimulating hormone (FSH), luteinizing hormone (LH), and
       testosterone in blood plasma. The average FSH and LH (in plasma or
       lymphocyte), testosterone, and LHRH concentrations in the 20
       FeLV-infected cats were measured by radioimmunoassay. The results were
       compared with those of the 12 control cats that were not FeLV-infected.
       Four weeks after infection, the plasma LHRH concentration in the
       infected cats showed a 43% reduction. Five to six weeks after infection,
       the content of FSH and LH in lymphocyte was reduced by 50% and 28%,
       respectively, whereas, the plasma FSH and LH was reduced by 52% and 42%,
       respectively. A significant reduction in testosterone content was
       detected at Week 11 of infection. The onset of the immuno- and
       neuroendocrine dysfunctions in FAIDs cats followed this sequence:
       hypothalamus, lymphocyte, pituitary, adrenal gland, and gonads. Indirect
       immunofluorescence assay showed the presence of FeLV cytoplasmic
       antigens in the fibers of the hypothalamic preoptic region and the
       Leydig cells. The possible causal relationship between the dysfunction
       of the lymphocyte and HPG systems and the presence of FeLV was
       discussed.
 DE    Animal  Cats  Cells, Cultured  Feline Acquired Immunodeficiency
       Syndrome/*IMMUNOLOGY/  *MICROBIOLOGY/PHYSIOPATHOLOGY  FSH/BLOOD
       Gonadorelin/BLOOD  Leukemia Virus, Feline/IMMUNOLOGY/*PHYSIOLOGY
       Lymphocytes/MICROBIOLOGY  LH/BLOOD  Male  Neurosecretory
       Systems/*PHYSIOPATHOLOGY  Support, Non-U.S. Gov't  Testosterone/BLOOD
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).