Document 0065
 DOCN  M9460065
 TI    Prevalence of human immunodeficiency virus (HIV) antibodies in
       tuberculosis patients in Lagos, Nigeria.
 DT    9408
 AU    Idigbe EO; Nasidi A; Anyiwo CE; Onubogu C; Alabi S; Okoye R; Ugwu O;
       John EK; Bacteriology Laboratory, National Institute for Medical
       Research,; Yaba, Lagos.
 SO    J Trop Med Hyg. 1994 Apr;97(2):91-7. Unique Identifier : AIDSLINE
       MED/94223746
 AB    To establish the prevalence of HIV antibodies in patients with pulmonary
       tuberculosis, 536 new cases presenting with symptoms of bronchopulmonary
       disorders were randomly selected from the six referral chest clinics in
       Lagos and screened for tuberculosis and HIV infections. Sputum and serum
       samples were obtained from all the patients. The sputum samples were
       examined for acid-fast bacilli (AFB) by both microscopy and culture. The
       sera were screened for HIV-1 and HIV-2 antibodies by ELISA and confirmed
       by Western blot (WB). Of the 536 cases studied, 188 (35%) were positive
       for AFB while 13 (2.4%) were seropositive for HIV. Correlation between
       the AFB and HIV results revealed that 10 (5.3%) of the 188 AFB positives
       were also seropositive for HIV as compared to 3 (0.9%) in the 348 AFB
       negative cases. The difference in the HIV seroprevalence rates in the
       two groups was statistically significant (P < 0.001). The recorded
       higher frequency of HIV infections in the AFB positives strongly
       suggested some level of interaction between TB and HIV infections in
       Lagos. Infections with HIV-2 were more prevalent than HIV-1 in the
       patients with HIV and TB. No case of dual infection with HIV-1 and HIV-2
       was recorded in this group of patients. However, in the 3
       HIV-seropositive patients within the control group (non-tuberculosis
       patients), 2 (67%) were positive for both HIV-1 and HIV-2 while 1 (33%)
       was positive for HIV-2 only. Mycobacterium tuberculosis (70%), M. avium
       (20%) and M. kansasii (10%) were the mycobacteria strains isolated from
       the HIV/TB infected patients.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adolescence  Adult  Antibodies, Viral/*BLOOD  AIDS-Related Opportunistic
       Infections/BLOOD/*EPIDEMIOLOGY/  IMMUNOLOGY/PREVENTION & CONTROL
       Blotting, Western  Chi-Square Distribution  Child  Enzyme-Linked
       Immunosorbent Assay  Female  Human  *HIV Seroprevalence
       *HIV-1/IMMUNOLOGY  *HIV-2/IMMUNOLOGY  Incidence  Male  Mass Screening
       Middle Age  Mycobacterium Infections,
       Atypical/*EPIDEMIOLOGY/MICROBIOLOGY/  PREVENTION & CONTROL
       Nigeria/EPIDEMIOLOGY  Pilot Projects  *Population Surveillance
       Seroepidemiologic Methods  Sputum/MICROBIOLOGY  Support, Non-U.S. Gov't
       Tuberculosis/*EPIDEMIOLOGY/MICROBIOLOGY/PREVENTION & CONTROL  *Urban
       Health  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).