Document 0069 DOCN M9460069 TI Viral persistence of simian type D retrovirus (SRV-2/W) in naturally infected pigtailed macaques (Macaca nemestrina). DT 9408 AU Moazed TC; Thouless ME; Department of Pathobiology, School of Public Health, University; of Washington, Seattle 98195. SO J Med Primatol. 1993 Sep-Oct;22(7-8):382-9. Unique Identifier : AIDSLINE MED/94223669 AB To elucidate sites of SRV-2/W persistence, tissue DNA from three groups of naturally infected Macaca nemestrina was analyzed for provirus: vertically transmitted, viremic, seronegative macaques; horizontally transmitted, viremic, seronegative macaques, and nonviremic seropositive macaques. In viremic animals infected vertically, provirus was found in many tissues, whereas in those infected horizontally, proviral DNA was limited. In V-Ab+ macaques, provirus was detected in bone marrow and/or ileocecal junction, confirming the presence of provirus in V-Ab+ animals. DE Animal DNA, Viral/ANALYSIS Female Macaca nemestrina/*MICROBIOLOGY Male Monkey Diseases/EPIDEMIOLOGY/*MICROBIOLOGY Prevalence Proviruses/ISOLATION & PURIF Retroviridae Infections/EPIDEMIOLOGY/MICROBIOLOGY/*VETERINARY Retroviruses Type D, Simian/GENETICS/IMMUNOLOGY/*ISOLATION & PURIF Seroepidemiologic Methods Simian Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY Support, U.S. Gov't, P.H.S. Tumor Virus Infections/EPIDEMIOLOGY/MICROBIOLOGY/*VETERINARY Viremia/MICROBIOLOGY/VETERINARY JOURNAL ARTICLE SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).