Document 0072
 DOCN  M9460072
 TI    [Immunohistological study of the nasal mucosa in latent allergic
       patients]
 DT    9408
 AU    Takasaki K; Yoshimi R; Takamura H; Kumagami H; Department of
       Otolaryngology, Nagasaki University.
 SO    Nippon Jibiinkoka Gakkai Kaiho. 1994 Feb;97(2):213-7. Unique Identifier
       : AIDSLINE MED/94223424
 AB    We studied the distribution of T lymphocyte subpopulations and EG2
       positive cells in the inferior turbinates of subjects with latent nasal
       allergy by use of an immunohistochemical procedure. Five patients who
       had a positive skin test for house dust and one who had a positive skin
       test for Japanese cedar were studied. The specimens were frozen at -70
       degrees C and sliced at 4 microns with a cryostat. The
       peroxidaseantiperoxidase method with monoclonal antibodies (CD4, CD8,
       EG2) was used to detect T lymphocyte subpopulations and activated
       eosinophils. Finally, the specimens were counterstained with Mayer's
       Hematoxylin. CD4 positive cells and CD8 positive cells were found mainly
       in the superficial layer of the lamina propria. In every subject, the
       number of CD4 positive cells dominated that of CD8 positive cells in the
       lamina propria. The ratio of CD4 positive cells to CD8 positive cells
       was 1.93, on average. This ratio was lower than the ratio typical of
       nasal allergy, but higher than the ratio of non-allergic normal
       controls. Though the number of EG2 positive cells was lower than the
       number typical of nasal allergy, EG2 positive cells were observed in
       every case. We speculate that latent nasal allergic reactions may
       develop in the inferior turbinates.
 DE    Adult  Blood Proteins/*ANALYSIS  CD4-CD8 Ratio  English Abstract  Female
       Hay Fever/*IMMUNOLOGY  Human  Immunohistochemistry  Male  Nasal
       Mucosa/*IMMUNOLOGY  Rhinitis, Allergic, Perennial/*IMMUNOLOGY
       T-Lymphocyte Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).