Document 0076
 DOCN  M9460076
 TI    Elevated levels of tumor necrosis factor-alpha in Zairian neonate
       plasmas: implications for perinatal infection with the human
       immunodeficiency virus.
 DT    9408
 AU    Brown CC; Poli G; Lubaki N; St. Louis M; Davachi F; Musey L; Manzila T;
       Kovacs A; Quinn TC; Fauci AS; Laboratory of Immunoregulation, National
       Institute of Allergy and; Infectious Diseases, National Institutes of
       Health, Bethesda,; Maryland 29892.
 SO    J Infect Dis. 1994 May;169(5):975-80. Unique Identifier : AIDSLINE
       MED/94223102
 AB    Plasma levels of tumor necrosis factor-alpha (TNF alpha) and the ability
       of plasmas to induce HIV expression in chronically infected cell lines
       were measured in samples from adults, cord blood, and neonates from
       Zaire and North America. Plasma levels of TNF alpha were higher in
       Zairian neonates born to HIV-negative and -positive mothers than in
       uninfected Zairian adults (612 vs. 128 vs. 8 pg/mL, P < .001); this
       dichotomy persisted until children were 9 months old. Plasmas from
       neonates of HIV-negative Zairian mothers also stimulated higher levels
       of reverse transcriptase from HIV-infected cell lines than did plasma
       from HIV-negative Zairian adults (1339 vs. 110 cpm, P < .001). Similar
       patterns were noted in plasmas from HIV-negative North American adults
       and neonates; however, TNF alpha levels were markedly lower, and smaller
       differences were noted among North American adults and neonates than
       those in the Zairian cohort. Markedly elevated plasma TNF alpha levels
       in Zairian neonates and infants may play a role in the pathogenesis and
       progression of HIV disease in this patient population.
 DE    Adult  Cell Line  Female  Human  HIV Infections/*BLOOD/PHYSIOPATHOLOGY
       *HIV-1/PHYSIOLOGY  Infant, Newborn  Pregnancy  Pregnancy Complications,
       Infectious/BLOOD/PHYSIOPATHOLOGY  Tumor Necrosis Factor/*ANALYSIS
       Up-Regulation (Physiology)  Virus Replication  Zaire  JOURNAL ARTICLE

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