Document 0086
 DOCN  M9460086
 TI    A longitudinal study of human papillomavirus DNA detection in human
       immunodeficiency virus type 1-seropositive and seronegative women.
 DT    9408
 AU    Vernon SD; Reeves WC; Clancy KA; Laga M; St. Louis M; Gary HE Jr; Ryder
       RW; Manoka AT; Icenogle JP; Division of Viral Diseases, Centers for
       Disease Control and; Prevention, Atlanta, Georgia 30333.
 SO    J Infect Dis. 1994 May;169(5):1108-12. Unique Identifier : AIDSLINE
       MED/94223073
 AB    Cericovaginal lavage samples from 124 human immunodeficiency virus type
       1 (HIV-1)-seropositive and 126 HIV-1-seronegative women were collected
       monthly for 8 months and tested for human papillomavirus (HPV) DNA. The
       estimated prevalence of HPV was 42.8% in HIV-1-seropositive and 13.4% in
       -seronegative women (P < .001). There was no significant difference in
       HPV DNA detection in HIV-1-seropositive women with CD4 cell counts of <
       300/mm3 (50% HPV-positive), 300-499/mm3 (36.4% HPV-positive), or > or =
       to 500/mm3 (40.5% HIV-positive). However, HIV-1-seropositive women who
       were more immunocompromised, as indicated by lower CD4 cell counts, were
       more likely to shed HPV persistently. The quantity of HPV DNA detected
       in cervicovaginal lavage samples was similar in HIV-1-seropositive and
       -seronegative women. This study further defined the characteristics of
       HPV infections in HIV-1-infected women.
 DE    Cervix Uteri/MICROBIOLOGY  Cohort Studies  DNA, Viral/ISOLATION & PURIF
       Female  Human  HIV Seronegativity  HIV Seropositivity/*COMPLICATIONS
       Longitudinal Studies  Papillomavirus, Human/GENETICS/*ISOLATION & PURIF
       Papovaviridae Infections/COMPLICATIONS/EPIDEMIOLOGY/*MICROBIOLOGY
       Prevalence  Prospective Studies  Support, Non-U.S. Gov't  Tumor Virus
       Infections/COMPLICATIONS/EPIDEMIOLOGY/*MICROBIOLOGY  Vagina/MICROBIOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).