Document 0113
 DOCN  M9460113
 TI    Tumour necrosis factor receptor levels are linked to the acute-phase
       response and malnutrition in human-immunodeficiency-virus-infected
       patients.
 DT    9408
 AU    Suttmann U; Selberg O; Gallati H; Ockenga J; Deicher H; Muller MJ;
       Abteilung Immunologie, Medizinische Hochschule, Hannover,; Germany.
 SO    Clin Sci (Colch). 1994 Apr;86(4):461-7. Unique Identifier : AIDSLINE
       MED/94221876
 AB    1. Increased release of tumour necrosis factor is thought to contribute
       to human-immunodeficiency-virus-associated wasting syndrome. Elevated
       serum concentrations of tumour necrosis factor have, however, mainly
       been found during acute opportunistic infections and were not correlated
       with the degree of wasting. This finding may be explained by the
       paracrine release and the rapid inactivation of tumour necrosis factor.
       Serum levels of the two recently detected soluble tumour necrosis factor
       receptor proteins (p55 and p75) are assumed to reflect tumour necrosis
       factor release. 2. Serum levels of soluble tumour necrosis factor
       receptors 55 and 75 were measured by an enzyme-linked immunological and
       biological binding assay in 45 human-immunodeficiency-virus-infected
       patients and seven healthy control subjects. Patients were followed up
       for survival. Serum albumin, prealbumin, total iron-binding capacity
       (transferrin) and C-reactive protein concentrations were measured using
       standard laboratory methods. Body composition was determined by
       bioelectrical impedance analysis. 3. Serum concentrations of soluble
       tumour necrosis factor receptor 55 and 75 were both significantly
       increased in human-immunodeficiency-virus-infected patients as compared
       with the health control subjects (P < 0.05); soluble tumour necrosis
       factor receptor concentrations were even more increased in patients with
       elevated C-reactive protein levels (> or = 5mg/l) as compared with those
       with normal C-reactive protein levels (< 5mg/l; P < 0.0001 and P < 0.01,
       respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Acute-Phase Reaction/*BLOOD  Adult  Aged  Body Composition/PHYSIOLOGY
       C-Reactive Protein/ANALYSIS  Comparative Study  Female  Human  HIV
       Seropositivity/*BLOOD/COMPLICATIONS  Male  Middle Age  Nutrition
       Disorders/*BLOOD/ETIOLOGY  Prognosis  Receptors, Tumor Necrosis
       Factor/*ANALYSIS  Serum Albumin/ANALYSIS  Tumor Necrosis Factor/ANALYSIS
       JOURNAL ARTICLE

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