Document 0117
 DOCN  M9460117
 TI    Hodgkin's disease associated with human immunodeficiency virus
       infection. A clinical study of 46 cases. Cooperative Study Group of
       Malignancies Associated with HIV Infection of Madrid.
 DT    9408
 AU    Rubio R; Unidad Infeccion HIV, Hospital 12 de Octubre, Madrid, Spain.
 SO    Cancer. 1994 May 1;73(9):2400-7. Unique Identifier : AIDSLINE
       MED/94221540
 AB    BACKGROUND. Hogdkin's disease is not an acquired immunodeficiency
       syndrome (AIDS)-defining illness. However, Hodgkin's disease associated
       with human immunodeficiency virus (HIV) infection has a different
       natural history and therapeutic outcome than in the general population
       of Hodgkin's disease patients. METHODS. The authors studied the
       epidemiologic and clinicopathologic features and therapeutic outcomes of
       46 patients with Hodgkin's disease associated with HIV infection
       collected from a cooperative study of nine hospitals in Madrid, Spain.
       RESULTS. Forty-three (93.5%) of the subjects were men and three (6.5%)
       were women, with a mean age of 26.9 years. Thirty-nine (84.8%) were
       intravenous drug users and four (8.7%) were homosexuals. In 43 patients
       (93.5%), Hodgkin's disease was the first manifestation of HIV infection.
       In 16 patients (34.8%), AIDS developed after the diagnosis of Hodgkin's
       disease. Histologic subtypes were mixed cellularity (41.3%), lymphoid
       depletion (21.7%), nodular sclerosis (21.7%), and lymphocytic
       predominance (4.3%). At diagnosis, 89.1% had advanced stages (III,IV),
       82.6% had B symptoms, and 41.3% had bone marrow involvement. Of 27
       evaluable patients treated with chemotherapy, 44.4% had a complete
       response (16.7% relapsed) and 37% had a partial response. Median
       survival was 15 months (range, 1-44 months). Projected 3-year survival
       rate was 19%, and projected event-free survival rate was 22% at 30
       months. Adverse prognostic factors for survival in univariate analysis
       were B symptoms, no response to chemotherapy, hemoglobin levels less
       than 11 g/dl, leukocyte count less than 4500/mm3, total lymphocyte count
       less than 1000/mm3, CD4 lymphocyte count less than 200/mm3, and alkaline
       phosphatase level greater than 300 IU/l. CONCLUSIONS. Hodgkin's disease
       associated with HIV infection is more frequent among intravenous drug
       addicts, and the clinical course is different in these patients from
       that in the general population of Hodgkin's disease patients, showing
       high frequency of advanced stages, unfavorable histologic subtypes, poor
       therapeutic response, and short survival time.
 DE    Adolescence  Adult  Antineoplastic Agents, Combined/THERAPEUTIC USE
       AIDS-Related Opportunistic Infections/EPIDEMIOLOGY  Cause of Death
       Combined Modality Therapy  Female  Follow-Up Studies  Hodgkin's
       Disease/DRUG THERAPY/*EPIDEMIOLOGY/*PATHOLOGY  Human  Lymphoma,
       AIDS-Related/DRUG THERAPY/*EPIDEMIOLOGY/PATHOLOGY  Male  Middle Age
       Neoplasm Staging  Prognosis  Remission Induction  Retrospective Studies
       Spain/EPIDEMIOLOGY  Survival Rate  JOURNAL ARTICLE  MULTICENTER STUDY

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