Document 0137
 DOCN  M9460137
 TI    Characterization of anergy to the superantigen Staphylococcus
       enterotoxin B.
 DT    9408
 AU    Dannecker G; Schultz H; Mecheri S; Sappler G; Clarke K; Niethammer D;
       Hoffmann MK; Department of Hematology/Oncology, Children's University;
       Hospital, Tubingen, Germany.
 SO    Immunodeficiency. 1993;4(1-4):137-9. Unique Identifier : AIDSLINE
       MED/94221108
 AB    In vivo administration of superantigens leads to activation and
       subsequent depletion or anergy of T cells expressing defined V beta-T
       cell receptors (TCR). Superantigens have therefore become intensively
       studied tools for examining parameters of immunoregulation and they may
       represent model antigens for pathogenic agents. An HIV-encoded
       superantigen has for example been implicated in the dramatic loss of
       helper T cells in AIDS. We investigated the response of V beta 8+ T
       cells in mice after primary and secondary exposure to the superantigen
       Staphylococcus Enterotoxin B (SEB).
 DE    Animal  Enterotoxins/ADMINISTRATION & DOSAGE/*IMMUNOLOGY  *Immune
       Tolerance  Immunization, Secondary  Lymphocyte Transformation  Mice
       Mice, Inbred BALB C  Receptors, Antigen, T-Cell, alpha-beta/METABOLISM
       Signal Transduction/IMMUNOLOGY  Staphylococcus aureus/*IMMUNOLOGY
       *Superantigens/ADMINISTRATION & DOSAGE  T-Lymphocyte Subsets/IMMUNOLOGY
       JOURNAL ARTICLE

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