Document 0142
 DOCN  M9460142
 TI    Human B cell interleukin 10.
 DT    9408
 AU    Benjamin D; Park CD; Sharma V; Division of Hematology and Oncology,
       Arthur G. James Cancer; Hospital and Research Institute, Columbus, Ohio
       43210.
 SO    Leuk Lymphoma. 1994 Jan;12(3-4):205-10. Unique Identifier : AIDSLINE
       MED/94220947
 AB    Interleukin 10 (IL-10) is a novel lymphokine which exhibits strong DNA
       and amino acid sequence homology to BCRF1, an open reading frame in the
       Epstein-Barr virus genome. Using a wide panel of EBV positive and EBV
       negative cell lines, it has been shown that EBV positive B cell lines
       derived from patients with AIDS and Burkitt's lymphoma (AABCL) secrete
       large quantities of B cell IL-10, compared with EBV-positive B cell
       lines obtained from patients with undifferentiated lymphomas of
       Burkitt's and non-Burkitt's types. In contrast, EBV-negative B cell
       lines do not express IL-10 by Northern blot analysis, ELISA or even PCR.
       B cell IL-10 is confined to a narrow window in the B cell
       differentiation pathway, and whereas IL-10 expression is detected in
       mature and preplasmacytic stages, none of the pro-B, pre-B, or myeloma
       cell lines produce IL-10. EBV exerts direct effect on the production of
       B cell IL-10, and purified tonsillar B cells infected with EBV were
       triggered to secrete IL-10. The large amount of IL-10 secreted by B
       cells derived from AIDS-related lymphomas suggests that HIV-1 also
       exerts direct effect on IL-10 secretion. B cell IL-10 may function as
       autocrine growth factor for B cell lymphomas, and both IL-10 and BCRF1
       seem to be involved in the pathophysiology of non-Hodgkin's lymphomas.
 DE    Amino Acid Sequence  B-Lymphocyte Subsets/IMMUNOLOGY
       B-Lymphocytes/*IMMUNOLOGY  Burkitt's Lymphoma/IMMUNOLOGY  Cell Line
       Comparative Study  Herpesvirus 4, Human/GENETICS  Human
       HIV-1/IMMUNOLOGY  Interleukin-10/*BIOSYNTHESIS/GENETICS  Lymphoma,
       AIDS-Related/IMMUNOLOGY  Polymerase Chain Reaction  Sequence Homology,
       Amino Acid  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Viral
       Proteins/GENETICS  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).