Document 0156
 DOCN  M9460156
 TI    Early and late cognitive event-related potentials mark stages of HIV-1
       infection in the drug-user risk group.
 DT    9408
 AU    Schroeder MM; Handelsman L; Torres L; Dorfman D; Rinaldi P; Jacobson J;
       Wiener J; Ritter W; Psychiatry Services, Veteran Affairs Medical Center,
       Bronx, NY; 10468.
 SO    Biol Psychiatry. 1994 Jan 1;35(1):54-69. Unique Identifier : AIDSLINE
       MED/94220545
 AB    HIV-1 (Human immunodeficiency virus) infection of the brain causes
       delays in auditory event-related potential (ERP) components. We recorded
       auditory ERPs from 38 former parenteral drug users (PDUs) at three
       stages of HIV-1 infection: seronegative; seropositive; stage II; and
       seropositive, stage IV. There were five response conditions: Go Nogo,
       Count, Simple Response, Simple Count, and Ignore. P3 peak latencies were
       significantly delayed and P3 amplitudes were significantly reduced for
       all seropositives, including asymptomatics, when compared to PDU
       seronegative controls. In contrast, the P1 and N1 peak latency measures
       were delayed only for seropositives with acquired immunodeficiency
       syndrome (AIDS) qualifying illnesses. There was a significant negative
       correlation between the CD4 count and the latency of P1, N1, and the
       MMN. Also, increased P1 and N1 amplitudes correlated with indices of
       disease progression (Choice RT and CD4 counts, respectively). The
       results extend previous findings by clarifying the pattern of auditory
       ERP markers of disease progression. Early, as well as late, brain
       involvement caused by HIV-1 is marked by delays and decreased amplitudes
       in cognitive components. In addition, late brain involvement is marked
       by delays and increased amplitudes in specific, automatic, and/or
       obligatory components.
 DE    Acquired Immunodeficiency Syndrome/DIAGNOSIS/*PHYSIOPATHOLOGY  Adult
       Attention/PHYSIOLOGY  AIDS Dementia
       Complex/DIAGNOSIS/*PHYSIOPATHOLOGY/PSYCHOLOGY  AIDS-Related
       Opportunistic Infections/DIAGNOSIS/PHYSIOPATHOLOGY/  PSYCHOLOGY
       Cerebral Cortex/PHYSIOPATHOLOGY  Evoked Potentials, Auditory/*PHYSIOLOGY
       Human  HIV Seropositivity/DIAGNOSIS/PHYSIOPATHOLOGY/PSYCHOLOGY  HIV-1
       Male  Middle Age  Pitch Discrimination/PHYSIOLOGY  Reaction
       Time/PHYSIOLOGY  Substance Abuse, Intravenous/COMPLICATIONS/DIAGNOSIS/
       *PHYSIOPATHOLOGY  Support, U.S. Gov't, Non-P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).