Document 0161
 DOCN  M9460161
 TI    Cerebrospinal fluid neopterin levels in 159 neurologically asymptomatic
       persons infected with the human immunodeficiency virus (HIV-1):
       relationship to immune status.
 DT    9408
 AU    Lucey DR; McGuire SA; Abbadessa S; Hall K; Woolford B; Valtier S; Butzin
       CA; Melcher GP; Hendrix CW; Department of Medicine, Wilford Hall USAF
       Medical Center,; Lackland AFB, Texas.
 SO    Viral Immunol. 1993 Winter;6(4):267-72. Unique Identifier : AIDSLINE
       MED/94220229
 AB    Monocytes and brain macrophage-microglial cells are thought to play a
       crucial role in the neurologic dysfunction associated with HIV-1
       disease. Since neopterin is produced by monocytes-macrophages, we asked
       whether cerebrospinal fluid (CSF) neopterin levels increase before the
       onset of HIV-1 neurologic disease and whether they correlate with other
       CSF and peripheral blood immunologic parameters. In this study, CSF
       neopterin levels from 159 neurologically asymptomatic HIV-positive
       persons were found to increase as the blood CD4+ T-cell count decreased
       and as CSF IgG, IgG synthesis, IgG index, and beta 2-microglobulin
       increased. Neopterin levels in the CSF exceeded those in the serum in
       32% of patients, while 25% had CSF levels > 13.5 nmol/liter. CSF
       neopterin levels vary with immune status, may reflect intrathecal
       production, and can be elevated in asymptomatic HIV-positive patients
       with normal neurologic examinations. Long-term follow-up of this patient
       population should be able to define the clinical correlation between CSF
       neopterin levels during the asymptomatic phase of HIV-1 disease and the
       risk of subsequent neurologic disease.
 DE    beta 2-Microglobulin/CEREBROSPINAL FLUID  Biopterin/*ANALOGS &
       DERIVATIVES/BLOOD/CEREBROSPINAL FLUID  Central Nervous
       System/*METABOLISM  Female  Human  HIV Seropositivity/*CEREBROSPINAL
       FLUID/IMMUNOLOGY  *HIV-1  IgG/CEREBROSPINAL FLUID  Leukocyte Count  Male
       T4 Lymphocytes  JOURNAL ARTICLE

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