Document 0176
 DOCN  M9460176
 TI    HIV vaccine trials: will intravenous drug users enroll?
 DT    9408
 AU    Meyers K; Metzger DS; Navaline H; Woody GE; McLellan AT; Center for
       Studies of Addiction, University of; Pennsylvania/Philadelphia
       Department of Veterans Affairs 19104.
 SO    Am J Public Health. 1994 May;84(5):761-6. Unique Identifier : AIDSLINE
       MED/94234404
 AB    OBJECTIVES. The purpose of this study was to assess the willingness of
       intravenous drug users to participate in a preventive human
       immunodeficiency virus (HIV) vaccine efficacy trial. METHODS. Of the 347
       intravenous drug users in methadone treatment who were approached for
       participation, 257 completed a battery of self-administered
       questionnaires assessing risk behaviors, interest in vaccine trials, and
       other vaccine-related information. Data from 16 known seropositives and
       1 inconsistent responder were dropped from analyses (n = 240). RESULTS.
       Fifty-two percent of the subjects expressed a willingness to be one of
       the first individuals to participate in a preventive HIV vaccine
       efficacy trial. Subjects who had recently shared needles or works and
       subjects who trusted the government to ensure vaccine safety were both
       twice as likely to report interest in participation. Twenty-two percent
       of subjects reported that they would increase needle sharing if
       vaccinated. Thirty percent did not know what a vaccine was. CONCLUSIONS.
       These findings suggest that some in-treatment intravenous drug users
       would volunteer for a preventive HIV vaccine efficacy trial. Education
       and counseling will be required to ensure that subjects fully understand
       the trial's purposes, methods, risks and benefits.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PREVENTION &  CONTROL
       Adult  *AIDS Vaccines  *Clinical Trials  Female  Human  Logistic Models
       Male  Middle Age  *Patient Acceptance of Health Care  *Substance Abuse,
       Intravenous/COMPLICATIONS/PSYCHOLOGY  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).