Document 0204
 DOCN  M9460204
 TI    Pathogenesis of SIVmac infection in Chinese and Indian rhesus macaques:
       effects of splenectomy on virus burden.
 DT    9408
 AU    Joag SV; Stephens EB; Adams RJ; Foresman L; Narayan O; Department of
       Microbiology, Marion Merrell Dow Laboratory of; Viral Pathogenesis,
       Kansas University Medical Center, Kansas City; 66160-7424.
 SO    Virology. 1994 May 1;200(2):436-46. Unique Identifier : AIDSLINE
       MED/94233707
 AB    The spleen and lymph nodes are the predominant sites of viral
       replication in SIV and HIV infections. We studied splenectomized and
       control unsplenectomized rhesus macaques of both the Indian and the
       Chinese subspecies of Macaca mulatta. All animals were inoculated with
       SIVmac239, a molecularly cloned strain of SIV. Our data showed: (1)
       splenectomized animals, particularly among the Indian subspecies, had a
       lower virus burden and longer survival than unsplenectomized controls,
       (2) the Chinese macaques controlled virus replication more effectively
       than did the Indian animals, and (3) that a higher infectious virus
       burden was present in LN/spleen than in blood in both splenectomized and
       control animals.
 DE    Animal  Antigens, CD8/IMMUNOLOGY  Base Sequence  China  Disease
       Susceptibility  Immunity, Cellular  India  Leukocytes,
       Mononuclear/MICROBIOLOGY  Lymph Nodes/CYTOLOGY/*MICROBIOLOGY  Macaca
       mulatta/*MICROBIOLOGY  Molecular Sequence Data  Polymerase Chain
       Reaction  Simian Acquired Immunodeficiency Syndrome/*ETIOLOGY  Species
       Specificity  Spleen/CYTOLOGY/*MICROBIOLOGY  Splenectomy  Support, U.S.
       Gov't, P.H.S.  Survival Analysis  SIV/ISOLATION & PURIF  JOURNAL ARTICLE

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