Document 0207
 DOCN  M9460207
 TI    Seroprevalence of human T-lymphotropic virus, hepatitis C virus, and
       human immunodeficiency virus in Asian American potential bone marrow
       donors.
 DT    9408
 AU    Sun M; Chao KH; Modahl LE; Leoung G; Khayam-Bashi H; Ng VL; Murphy EL;
       Department of Medicine, University of California, San Francisco.
 SO    Transfusion. 1994 Apr;34(4):344-8. Unique Identifier : AIDSLINE
       MED/94233584
 AB    BACKGROUND: Asian Americans are generally underrepresented both as
       volunteer blood and bone marrow donors. STUDY DESIGN AND METHODS: To
       investigate the risk of transfusion transmission of viruses that is
       associated with increasing participation by Asian American donors,
       antibodies to human T-lymphotropic virus (HTLV), hepatitis C, and human
       immunodeficiency virus in Asian American volunteers recruited as
       potential bone marrow donors were measured. A total of 1354 Asian
       Americans were enrolled in the study, of whom 54 percent were Chinese,
       26 percent Japanese, 9 percent Filipino, 4 percent Korean, 3 percent
       Indian, and 5 percent of other Asian or mixed Asian and other ethnicity.
       The majority of the study population was aged 20 through 49 and of high
       socioeconomic status, as indicated by education and income. Viral
       antibodies were measured with both screening enzyme-linked immunosorbent
       assays and supplemental testing, and polymerase chain reaction was used
       to resolve discrepant HTLV results. RESULTS: Confirmed seroprevalence
       rates for HTLV were 0.15 percent with one manufacturer's Western blot
       and 0.3 percent with the other; however, no sample was positive for HTLV
       types I or II in polymerase chain reaction. Confirmed seroprevalence to
       hepatitis C virus was 0.5 percent. No subject was seropositive for human
       immunodeficiency virus. CONCLUSION: On the basis of the moderate size
       and high education level of this study population, it is concluded that
       Asian American volunteer bone marrow donors do not pose a greater risk
       for transmission of HTLV type I or II, human immunodeficiency virus, or
       hepatitis C virus than does the average American blood donor.
 DE    Adolescence  Adult  Antibodies, Viral/BLOOD  Asia/ETHNOLOGY  *Bone
       Marrow Transplantation  Hepatitis C  Human  *HIV Seroprevalence  HTLV-I
       Infections/EPIDEMIOLOGY  HTLV-II Infections/EPIDEMIOLOGY  Middle Age
       Prevalence  Support, Non-U.S. Gov't  *Tissue Donors  United
       States/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).