Document 0225
 DOCN  M9460225
 TI    Serologic response to standard inactivated influenza vaccine in human
       immunodeficiency virus-infected children.
 DT    9408
 AU    Chadwick EG; Chang G; Decker MD; Yogev R; Dimichele D; Edwards KM;
       Department of Pediatrics, Northwestern University Medical School,;
       Chicago, IL.
 SO    Pediatr Infect Dis J. 1994 Mar;13(3):206-11. Unique Identifier :
       AIDSLINE MED/94232702
 AB    We compared the serologic response of 46 human immunodeficiency virus
       (HIV)-infected children and adolescents and 61 age-matched controls to
       standard trivalent inactivated influenza vaccine (A/Taiwan (H1N1),
       A/Shanghai (H3N2), B/Yamagata). Children were immunized according to the
       package insert recommendations before the 1990 to 1991 influenza season.
       Serum antibody titers to influenza A were determined before and 1 month
       after each vaccination and compared for study and control subjects.
       Serologic responses of HIV-infected participants were correlated with
       absolute CD4 counts and stage of HIV disease. Regardless of age or HIV
       status, all groups responded with significant increases in antibody to
       the influenza A strains (range, 2.1-fold to 11.8-fold), with the
       exception that antibody to H3N2 rose only 1.5-fold (P = 0.058) among
       HIV-positive subjects > or = 9 years old. Pre- and postimmunization
       antibody titers were significantly higher for controls than for
       HIV-positive subjects. There was no correlation between serologic
       responses and CD4 counts among HIV-infected subjects, but those with
       Centers for Disease Control and Prevention-defined acquired
       immunodeficiency syndrome responded significantly less well to vaccine.
       We conclude that HIV-infected children and adolescents produce
       significant antibody rises after inactivated influenza A vaccination but
       that their absolute antibody concentrations are lower than those seen in
       age-matched controls.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Adolescence  Antibodies,
       Viral/*BIOSYNTHESIS/IMMUNOLOGY  Child, Preschool  Comparative Study
       Female  Human  Infant  Influenza Vaccine/*IMMUNOLOGY  Male
       Orthomyxoviridae Infections/*PREVENTION & CONTROL  Orthomyxovirus Type
       A, Human/*IMMUNOLOGY  Risk Factors  Support, U.S. Gov't, P.H.S.
       Vaccination  Vaccines, Inactivated/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).