Document 0239
 DOCN  M9460239
 TI    Manifestations of Epstein-Barr virus-associated disorders in liver.
 DT    9408
 AU    Markin RS; Department of Pathology and Microbiology, University of
       Nebraska; Medical Center, Omaha 68198-3135.
 SO    Liver. 1994 Feb;14(1):1-13. Unique Identifier : AIDSLINE MED/94231939
 AB    Epstein-Barr virus is a ubiquitous virus associated with a variety of
       different diseases and disorders. The manifestations of Epstein-Barr
       virus-associated diseases or disorders within the liver, which involve a
       broad spectrum of histologic and clinical features, ranging from
       hepatitis through lymphoproliferative disorders to lymphoma, are
       presented. An important aspect of Epstein-Barr virus expression and
       infection is the biology of the Epstein-Barr virus. Documentation of
       infection can be performed using serology to detect the interaction of
       Epstein-Barr virus with the immune system, and the detection of EBV
       proteins and use of molecular biologic techniques to identify the
       presence of EBV RNA, and DNA sequences. Of particular utility are in
       situ hybridization, Southern blot analysis, and polymerase chain
       reaction as diagnostic methods to identify specific RNA or DNA
       sequences. Epstein-Barr virus-associated diseases and disorders
       including infectious mononucleosis, sporadic fatal infectious
       mononucleosis, X-linked proliferative disorder (Duncan's disease),
       post-transplant lymphoproliferative disorders, lymphoma, and AIDS are
       discussed. The histopathologic findings present in liver associated with
       each disease are presented with illustrative examples. Handling the
       tissue and interaction with clinical services are also discussed as a
       method for appropriate diagnosis of Epstein-Barr virus-driven processes
       affecting the liver.
 DE    Acquired Immunodeficiency Syndrome/MICROBIOLOGY  *Herpesviridae
       Infections  *Herpesvirus 4, Human  Hodgkin's Disease/MICROBIOLOGY  Human
       Infectious Mononucleosis/MICROBIOLOGY  Liver/*MICROBIOLOGY  Liver
       Diseases/*MICROBIOLOGY  Lymphoma, Non-Hodgkin's/MICROBIOLOGY
       Lymphoproliferative Disorders/MICROBIOLOGY  *Tumor Virus Infections
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).