Document 0241
 DOCN  M9460241
 TI    Perioperative allogeneic blood transfusion exacerbates surgical
       stress-induced postoperative immunosuppression and has a negative effect
       on prognosis in patients with gastric cancer.
 DT    9408
 AU    Maeta M; Shimizu N; Oka A; Kondo A; Yamashiro H; Tsujitani S; Ikegchi M;
       Kaibara N; First Department of Surgery, Tottori University School of;
       Medicine, Yonago, Japan.
 SO    J Surg Oncol. 1994 Mar;55(3):149-53. Unique Identifier : AIDSLINE
       MED/94231771
 AB    The immunomodulative effect of perioperative allogeneic blood
       transfusion on host immunocompetence was studied in 109 patients with
       gastric cancer at various stages. Mitogen-induced lymphocyte
       blastogenesis, lymphocyte surface markers (specific for T, B, CD4, and
       CD8 populations), and the activity of natural killer (NK) cells were
       examined before surgery and then 2 and 4 weeks after surgery. The
       effects on host immunocompetence of transfusion alone, in the absence of
       any effect of surgical stress, were studied, preoperatively, in nine
       patients who received preoperative transfusion. Although a tendency
       towards a decrease in the posttransfusion activity of NK cells was
       observed, there were no statistically significant differences between
       pre- and posttransfusion levels. Mitogen-induced blastogenesis and the
       activity of NK cells were significantly impaired 2 weeks after surgery
       in transfused patients as compared to those in nontransfused patients
       with gastric cancer at stage III and stage IV, and postoperative
       survival was significantly lower in transfused as compared to
       nontransfused patients. These results indicate that perioperative
       allogeneic blood transfusion exacerbates surgical stress-induced
       postoperative immunosuppression and has a negative effect on prognosis
       in patients with gastric cancer.
 DE    Blood Transfusion/*ADVERSE EFFECTS  Comparative Study  CD4-CD8 Ratio
       Human  Immunocompetence/PHYSIOLOGY  Immunocompromised Host/*IMMUNOLOGY
       Killer Cells, Natural/IMMUNOLOGY  Lymphocyte Transformation/IMMUNOLOGY
       Postoperative Complications/*IMMUNOLOGY  Prognosis  Stomach
       Neoplasms/*IMMUNOLOGY/MORTALITY/SURGERY  Stress/*IMMUNOLOGY  JOURNAL
       ARTICLE

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