Document 0267
 DOCN  M9460267
 TI    Risk factors for anal human papillomavirus infection and anal cytologic
       abnormalities in HIV-positive and HIV-negative homosexual men.
 DT    9408
 AU    Palefsky JM; Shiboski S; Moss A; Department of Laboratory Medicine,
       University of California, San; Francisco 94143.
 SO    J Acquir Immune Defic Syndr. 1994 Jun;7(6):599-606. Unique Identifier :
       AIDSLINE MED/94231465
 AB    Men with advanced human immunodeficiency virus (HIV) disease have a high
       prevalence of anal human papillomavirus (HPV) infection and potentially
       precancerous anal disease. To characterize prevalence of and risk
       factors for anal HPV infection and anal cytologic abnormalities, 37
       HIV-positive and 28 HIV-negative participants in the San Francisco
       General Hospital Cohort Study were studied. A questionnaire was
       administered, followed by an anal examination consisting of two
       consecutive anal swabs for cytology and HPV DNA hybridization, and
       anoscopy with biopsy of visible lesions. Ten of 28 (36%) HIV-negative
       men and 19 of 37 (51%) HIV-positive men had anal HPV infection (p =
       0.32). Risk factors for anal HPV infection included HIV positivity with
       a CD4 count < 200/mm3 (p = 0.03) and a history of smoking (p = 0.03).
       Abnormal anal cytology was found in 2 of 26 (8%) HIV-negative men and 10
       of 36 (28%) HIV-positive men with cytology adequate for interpretation
       (p = 0.09). Risk factors for abnormal anal cytology included HIV
       positivity with a CD4 count < 200/mm3 (p = 0.006) and current smoking (p
       = 0.03). We conclude that the risk of development of anal disease and
       HPV infection was highest among HIV-positive men with a CD4 count of <
       200/mm3, and that smoking may play a role in the pathogenesis of anal
       disease.
 DE    Adult  Analysis of Variance  Anus/*PATHOLOGY  Cohort Studies  DNA
       Probes, HPV  *Homosexuality  Human  HIV Seropositivity/*COMPLICATIONS
       Male  Multivariate Analysis  Odds Ratio  *Papillomavirus, Human
       Papovaviridae Infections/EPIDEMIOLOGY/*ETIOLOGY  Prevalence  Prospective
       Studies  Risk Factors  Smoking/ADVERSE EFFECTS  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  Tumor Virus
       Infections/EPIDEMIOLOGY/*ETIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).