Document 0269
 DOCN  M9460269
 TI    Anti-lipopolysaccharide antibody levels in patients with AIDS at the
       onset of Pseudomonas aeruginosa bacteremia.
 DT    9408
 AU    Kumar PN; Collins MS; Pierce PF; Division of Infectious Diseases,
       Georgetown University Hospital,; Washington, D.C.
 SO    J Acquir Immune Defic Syndr. 1994 Jun;7(6):587-91. Unique Identifier :
       AIDSLINE MED/94231463
 AB    Lipopolysaccharide (LPS) in the cell wall of the P. aeruginosa is a
       major factor in the pathogenicity and virulence of this organism.
       Immunotype-specific serum antibodies to this LPS antigen (ALPS) are
       usually elevated with the onset of the bacteremia, act as opsonins, are
       protective in high levels, and are significantly associated with
       improved survival. In the present study, the ability of 11 patients with
       AIDS to mount a specific ALPS response with the onset of P. aeruginosa
       bacteria was evaluated prospectively. Of the 11 patients with AIDS only
       one had a substantial ALPS response, six mounted only a marginal ALPS
       response, and four had no ALPS response to the infecting strain of the
       P. aeruginosa. These data suggest most patients with AIDS do not exhibit
       a marked antigen-specific humoral response at the onset of P. aeruginosa
       bacteremia; this has important prognostic and therapeutic significance,
       as high ALPS titers are associated with survival.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY/  MORTALITY
       Adult  Antibodies, Bacterial/BLOOD  Bacteremia/COMPLICATIONS/*IMMUNOLOGY
       Female  Human  IgG/BLOOD  Lipopolysaccharides/*IMMUNOLOGY  Male  Middle
       Age  Opsonins/IMMUNOLOGY  Prognosis  Prospective Studies  Pseudomonas
       aeruginosa/*IMMUNOLOGY  Pseudomonas
       Infections/COMPLICATIONS/*IMMUNOLOGY/MORTALITY  Risk Factors  Support,
       Non-U.S. Gov't  Survival Rate  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).