Document 0271
 DOCN  M9460271
 TI    Cytotoxic T-lymphocytes that kill autologous CD4+ lymphocytes are
       associated with CD4+ lymphocyte depletion in HIV-1 infection.
 DT    9408
 AU    Grant MD; Smail FM; Rosenthal KL; Department of Pathology, McMaster
       University, Hamilton, Ontario,; Canada.
 SO    J Acquir Immune Defic Syndr. 1994 Jun;7(6):571-9. Unique Identifier :
       AIDSLINE MED/94231461
 AB    Human immunodeficiency virus type 1 (HIV-1)-infected individuals, but
       not HIV-seronegative controls, have non-HLA-restricted T-cell receptor
       alpha beta+ CD8+ cytotoxic T-lymphocytes (CTL) that kill activated
       uninfected CD4+ lymphocytes. In vitro stimulation of peripheral blood
       mononuclear cells from HIV-1-infected individuals with concanavalin A
       (Con A) or by coculture with phytohemagglutinin-activated autologous
       lymphoblasts induced CTL that killed autologous and heterologous CD4+
       lymphocytes, but not Con A-activated CD8+ lymphocytes or Epstein-Barr
       virus (EBV)-transformed B lymphocytes. EBV did not stimulate such CTL in
       two subjects tested, although stimulation with Con A or autologous
       lymphoblasts induced CTL activity against CD4+ lymphocytes in both
       subjects. CTL activity against autologous CD4+ lymphocytes varied over
       time; killing of heterologous CD4+ lymphocytes was often higher than
       that of autologous CD4+ lymphocytes. HIV-infected individuals with Con
       A-inducible CTL against autologous CD4+ lymphocytes lost more CD4+
       lymphocytes within 6 months of testing than HIV-infected individuals
       with no such CTL (p < .01). The mean (+/- SD) decrease in CD4+
       lymphocyte counts in a group of HIV-infected individuals with CTL
       activity against autologous CD4+ lymphocytes was 121 +/- 84, or 36%, of
       total CD4+ lymphocytes over 6 months. In contrast, there was no
       significant change in mean CD4+ lymphocyte count over 6 months in a
       group of HIV-infected individuals without CTL activity against
       autologous CD4+ lymphocytes. In some HIV-infected individuals, CTL
       activity against autologous CD4+ lymphocytes fell coincident with a drop
       in CD4+ lymphocyte number in vivo.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Cytotoxicity, Immunologic  Follow-Up Studies  Herpesvirus 4,
       Human/IMMUNOLOGY  Human  HIV Infections/*IMMUNOLOGY  Lymphocyte
       Transformation  Support, Non-U.S. Gov't  T-Lymphocytes,
       Cytotoxic/*IMMUNOLOGY  T4 Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).