Document 0279
 DOCN  M9460279
 TI    Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV
       principles from Syzigium claviflorum, and the anti-HIV activity of
       structurally related triterpenoids.
 DT    9408
 AU    Fujioka T; Kashiwada Y; Kilkuskie RE; Cosentino LM; Ballas LM; Jiang JB;
       Janzen WP; Chen IS; Lee KH; Natural Products Laboratory, Division of
       Medicinal Chemistry,; University of North Carolina, Chapel Hill 27599.
 SO    J Nat Prod. 1994 Feb;57(2):243-7. Unique Identifier : AIDSLINE
       MED/94231196
 AB    Betulinic acid [1] and platanic acid [2], isolated from the leaves of
       Syzigium claviforum, were found to be inhibitors of HIV replication in
       H9 lymphocyte cells. Evaluation of anti-HIV activity with eight
       derivatives of 1 revealed that dihydrobetulinic acid [3] was also a
       potent inhibitor of HIV replication. The C-3 hydroxy group and C-17
       carboxylic acid group, as well as the C-19 substituents, contribute to
       enhanced anti-HIV activity. The inhibitory activity of these compounds
       against protein kinase C (PKC) was also examined, since a correlation
       between anti-HIV and anti-PKC activities has been suggested. However,
       there was no apparent correlation between anti-HIV activity and the
       inhibition of PKC among these compounds.
 DE    Antiviral Agents/*ISOLATION & PURIF/PHARMACOLOGY  Cells, Cultured  Human
       HIV-1/*DRUG EFFECTS/PHYSIOLOGY  Lymphocytes/MICROBIOLOGY  Plants,
       Medicinal/*CHEMISTRY  Protein Kinase C/ANTAGONISTS & INHIB  Support,
       U.S. Gov't, P.H.S.  Triterpenes/*ISOLATION & PURIF/PHARMACOLOGY  Virus
       Replication/DRUG EFFECTS  JOURNAL ARTICLE

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