Document 0280
 DOCN  M9460280
 TI    Swertifrancheside, an HIV-reverse transcriptase inhibitor and the first
       flavone-xanthone dimer, from Swertia franchetiana.
 DT    9408
 AU    Wang JN; Hou CY; Liu YL; Lin LZ; Gil RR; Cordell GA; Department of
       Phytochemistry, Institute of Medicinal Plant; Development, Beijing,
       People's Republic of China.
 SO    J Nat Prod. 1994 Feb;57(2):211-7. Unique Identifier : AIDSLINE
       MED/94231192
 AB    The first flavone-xanthone C-glucoside, swertifrancheside, was isolated
       from Swertia franchetiana, and its structure was elucidated on the basis
       of spectroscopic analysis as
       1,5,8-trihydroxy-3-methoxy-7-(5',7',3'',4''-
       tetrahydroxy-6'-C-beta-D-glucopyranosyl-4'-oxy-8'-flavyl)-xanthon- e .
       This compound was a moderately potent inhibitor of HIV reverse
       transcriptase.
 DE    Antimalarials/PHARMACOLOGY  Antineoplastic Agents,
       Phytogenic/PHARMACOLOGY  Cell Survival/DRUG EFFECTS  Drug Screening
       Assays, Antitumor  Flavones/*ISOLATION & PURIF/PHARMACOLOGY  Human
       HIV-1/*ENZYMOLOGY  Molecular Conformation  Nuclear Magnetic Resonance
       Plants, Medicinal/*CHEMISTRY  Reverse Transcriptase/*ANTAGONISTS & INHIB
       Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Xanthenes/*ISOLATION & PURIF/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).