Document 0281
 DOCN  M9460281
 TI    Neurological abnormalities associated with feline immunodeficiency virus
       infection.
 DT    9408
 AU    Phillips TR; Prospero-Garcia O; Puaoi DL; Lerner DL; Fox HS; Olmsted RA;
       Bloom FE; Henriksen SJ; Elder JH; Department of Neuropharmacology,
       Scripps Research Institute, La; Jolla, California 92037.
 SO    J Gen Virol. 1994 May;75 ( Pt 5):979-87. Unique Identifier : AIDSLINE
       MED/94231177
 AB    Specific pathogen-free cats were infected with the Maryland strain of
       FIV (FIV-MD) for the purpose of assessing the effects of FIV infection
       on the central nervous system (CNS). Two separate studies were
       performed, involving a total of 13 infected cats and six age-matched,
       sham-inoculated controls. All animals infected with FIV-MD seroconverted
       by 8 weeks post-infection and virus was recovered from peripheral blood
       mononuclear cells of all infected cats. All of the infected animals had
       lower absolute CD4+ cells counts and decreased CD4+/CD8+ ratios. Virus
       was recovered from the cerebrospinal fluid (CSF) of certain infected
       individuals, and antiviral antibody and pleocytosis were evident in the
       CSF of the majority of infected cats. Additionally, virus was recovered
       from tissue explants from the cerebellum, midbrain and brainstem of one
       sacrificed FIV+ cat. Specific neurological changes included anisocoria,
       delayed righting reflex and delayed pupillary reflex, as well as delayed
       visual and auditory evoked potentials, and marked alterations in sleep
       patterns similar to those reported for human immunodeficiency virus
       (HIV)-positive individuals. Histological evaluation revealed the
       presence of perivascular cuffing and glial nodules in FIV-infected cats.
       These results indicate that FIV causes an acute neurological disease
       that closely resembles the early neurological effects of HIV infection
       in humans and should serve well as an animal model for
       lentivirus-induced CNS disease.
 DE    Acute Disease  Animal  Brain Diseases/*PHYSIOPATHOLOGY  Cats
       Equilibrium  Evoked Potentials, Auditory  Evoked Potentials, Visual
       Eye/PATHOLOGY  Hippocampus/PATHOLOGY  *Immunodeficiency Virus, Feline
       Lentivirus Infections/*PHYSIOPATHOLOGY  Reflex, Pupillary  Sleep
       Specific Pathogen-Free Organisms  Support, U.S. Gov't, P.H.S.  JOURNAL
       ARTICLE

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