Document 0301
 DOCN  M9460301
 TI    [Adjuvant corticoid administration within the scope of HIV disease.
       Indications in wasting syndrome and other diseases within the scope of
       AIDS]
 DT    9408
 AU    Jager H; KIS-Kuratorium fur Immunschwache, Munchen.
 SO    Fortschr Med. 1994 Mar 10;112(7):87-91. Unique Identifier : AIDSLINE
       MED/94229699
 AB    While at the start of the AIDS epidemic, corticosteroids were considered
       to be contraindicated, about 10 indications have since been identified
       for the specific use of glucocorticoids in HIV infection. Some of these
       indications have already been confirmed in controlled scientific
       studies, for example, pneumocystis carinii pneumonia or HIV-induced
       high-grade non-Hodgkin's lymphoma. In the case of other indications, for
       example, cerebral toxoplasmosis or certain forms of the wasting
       syndrome, clinical observational studies and, in particular, empirical
       data provided by large groups working on AIDS, are available. The use of
       corticoids for such other indications as pulmonary involvement in the
       case of Kaposi's sarcoma, or thrombopenia in HIV patients, is still
       experimental. To date, the initially feared high rate of side effects
       due to the theoretically possible impairment of immunological function,
       has not been observed. The effect of the corticosteroids appears to be
       concentrated more in their anti-inflammatory action than in substitution
       in the event of adrenal insufficiency. The carefully considered and
       selective use of corticosteroids can both improve the quality of life
       and lengthen the life expectancy of many HIV victims.
 DE    Adrenal Cortex Hormones/*ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/
       CONTRAINDICATIONS  AIDS-Related Opportunistic Infections/*DRUG THERAPY
       Cachexia/*DRUG THERAPY  Dose-Response Relationship, Drug  Drug
       Administration Schedule  English Abstract
       Glucocorticoids/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/
       CONTRAINDICATIONS  Human  HIV Infections/*DRUG THERAPY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

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