Document 0311
 DOCN  M9460311
 TI    Inactivation of HIV, HBV, HCV related viruses and other viruses in human
       plasma derivatives by pasteurisation.
 DT    9408
 AU    Nowak T; Niedrig M; Bernhardt D; Hilfenhaus J; Microbiology Research
       Laboratories, Behringwerke AG, Marburg,; Germany.
 SO    Dev Biol Stand. 1993;81:169-76. Unique Identifier : AIDSLINE
       MED/94229370
 AB    Laboratory studies were made to verify the capacity and efficacy of the
       pasteurisation step (heat treatment at 60 degrees C for 10 hours in
       stabilized aqueous solution) in inactivating various pathogenic viruses
       (e.g. HIV, HBV, HCV related viruses, HAV, HSV, poliovirus). These
       experiments proved that pasteurisation effectively inactivates a broad
       spectrum of viruses with a range of different physicochemical
       properties. The results, summarized in inactivation kinetics,
       demonstrate that complete inactivation of high quantities of both
       enveloped (e.g. HIV, HCV related viruses) and non-enveloped (e.g.
       poliovirus) viruses takes place during pasteurisation. In clinical
       trials on the virus safety of plasma derivatives no case of AIDS,
       hepatitis B or C occurred. From these data we conclude that heat
       treatment at 60 degrees C in a stabilized aqueous solution confers a
       high margin of safety on human plasma protein preparations regarding the
       transmission of diseases such as AIDS or hepatitis.
 DE    *Biological Products  Clinical Trials  Drug Contamination/PREVENTION &
       CONTROL  Flaviviridae/PHYSIOLOGY  *Heat  Hepatitis B Virus/*PHYSIOLOGY
       Hepatitis C Viruses/*PHYSIOLOGY  Human  HIV/*PHYSIOLOGY  Kinetics
       Picornaviridae/PHYSIOLOGY  Plasma/*MICROBIOLOGY  Prospective Studies
       Safety  Virus Diseases/PREVENTION & CONTROL  Virus Replication  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).