Document 0314
 DOCN  M9460314
 TI    Management of human papilloma virus vulvo-perineal infection with
       systemic beta-interferon and thymostimulin in HIV-positive patients.
 DT    9408
 AU    Frega A; di Renzi F; Stentella P; Pachi A; II Clinic of Obstetrics and
       Gynecology, University of Rome La; Sapienza, Italy.
 SO    Int J Gynaecol Obstet. 1994 Mar;44(3):255-8. Unique Identifier :
       AIDSLINE MED/94229320
 AB    OBJECTIVES: To evaluate the effect of a combined therapy based on
       beta-interferon and thymostimulin in HIV-seropositive women with florid
       vulvoperineal condylomatosis. METHODS: Nineteen HIV-seropositive women
       affected by HPV florid vulvo-perineal infection were studied. Their ages
       ranged from 19 to 32 years (mean = 26); all were smokers; 11 (57.89%)
       were intravenous drug users with a mean period of drug addiction of 5
       years. No patient was on AZT therapy. All patients underwent a combined
       medical therapy based on beta-interferon administration with doses of
       3,000,000 IU i.m. daily for 7 days and subsequently on alternate days
       for 2 weeks associated with the administration of 70 mg i.m. of
       thymostimulin per day on alternate days for 30 days. RESULTS: Seven
       (36.84%) patients showed complete recovery at the end of follow-up; 5
       (26.31%) patients showed partial recovery and 7 (36.84%) did not respond
       to therapy. CONCLUSION: A pro-host immunotherapy seems to be indicated
       in patients affected by immunodeficiency syndrome.
 DE    Adjuvants, Immunologic/THERAPEUTIC USE  Adult  AIDS-Related
       Opportunistic Infections/MICROBIOLOGY/*THERAPY  Condylomata
       Acuminata/*THERAPY  Female  Human  HIV Seropositivity/*MICROBIOLOGY
       Interferon Inducers/*THERAPEUTIC USE  Interferon-beta/*THERAPEUTIC USE
       *Papillomavirus, Human  Papovaviridae Infections/*THERAPY
       Perineum/MICROBIOLOGY  Substance Abuse, Intravenous/COMPLICATIONS
       Thymus Extracts/*THERAPEUTIC USE  Vulvar Diseases/*MICROBIOLOGY/THERAPY
       JOURNAL ARTICLE

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