Document 0322
 DOCN  M9460322
 TI    Quantitative EEG in patients with AIDS and asymptomatic HIV infection.
 DT    9408
 AU    Newton TF; Leuchter AF; Miller EN; Weiner H; Department of Psychiatry,
       Department of Veterans' Affairs Medical; Center, West Los Angeles, CA
       90073.
 SO    Clin Electroencephalogr. 1994 Jan;25(1):18-25. Unique Identifier :
       AIDSLINE MED/94228728
 AB    Although neuropsychiatric abnormalities are common in subjects with the
       acquired immunodeficiency syndrome (AIDS), they are less frequent in
       asymptomatic human immunodeficiency virus (HIV) seropositive subjects.
       In contrast, others have reported high rates of electroencephalographic
       (EEG) abnormality among asymptomatic subjects. Here we report clinical
       and quantitative EEG findings across all stages of the disease in order
       to define when during the course of illness abnormalities are
       detectable. We studied 28 men with AIDS, 32 men with asymptomatic HIV
       infection, and 56 uninfected controls using clinical and quantitative
       EEG, measures of immunosuppression, and tests of neuropsychological
       performance. All were gay or bisexual without other significant risk
       factors for encephalopathy. We found very low rates of clinical EEG
       abnormality (less than 7%) among the asymptomatic HIV-infected group, a
       rate comparable to those of the uninfected group (7.1%). There were no
       differences between asymptomatic HIV-seropositive subjects and
       uninfected controls on quantitative EEG measures. Among AIDS patients
       28.6% had abnormal clinical electroencephalograms. On quantitative
       measures, the greatest differences were found in the 6-10 Hz band, where
       AIDS patients had consistently increased absolute power, relative power,
       and coherence compared to the uninfected and asymptomatic seropositive
       groups. A subgroup (n = 9) of asymptomatic HIV-seropositive subjects had
       worsening performance on Trailmaking test, part B, at or after the time
       of recording. This subgroup had quantitative electroencephalographic
       measures similar to those of the AIDS patients and different from the
       remainder of the asymptomatic HIV-seropositive group.(ABSTRACT TRUNCATED
       AT 250 WORDS)
 DE    Adult  AIDS Dementia Complex/DIAGNOSIS/*PHYSIOPATHOLOGY  Bisexuality
       Brain Mapping  Cerebral Cortex/PHYSIOPATHOLOGY
       Electroencephalography/*CLASSIFICATION/INSTRUMENTATION  Homosexuality
       Human  HIV Seropositivity/DIAGNOSIS/*PHYSIOPATHOLOGY  Male
       Microcomputers  Middle Age  Signal Processing,
       Computer-Assisted/INSTRUMENTATION  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).