Document 0324
 DOCN  M9460324
 TI    Changes in plasma amino acid concentrations in response to HIV-1
       infection.
 DT    9408
 AU    Hortin GL; Landt M; Powderly WG; Department of Pathology, University of
       Alabama at Birmingham; 35233.
 SO    Clin Chem. 1994 May;40(5):785-9. Unique Identifier : AIDSLINE
       MED/94228692
 AB    Plasma concentrations of 21 amino acids were determined for 20 control
       subjects and 20 subjects infected with human immunodeficiency virus type
       1 (HIV). Compared with the control subjects, the HIV-infected group had
       lower cystine, tryptophan, and methionine (decreased 67%, 52%, and 32%,
       respectively, P < 0.001 for each) and increased taurine (230%, P <
       0.001) and lysine concentrations (30%, P < 0.001). Other amino acid
       concentrations changed modestly. Amounts of cystine, tryptophan,
       methionine, taurine, and lysine did not differ significantly between
       subgroups of HIV-infected subjects with > 200 (n = 6) or < 200 (n = 14)
       CD4+ lymphocytes per microliter, suggesting that the concentrations
       decrease soon after infection and change little thereafter. Activation
       of metabolism of cystine to taurine may explain reciprocal changes in
       these amino acids and known depletion of cystine and glutathione. The
       selective changes in amino acid profiles observed during HIV infection
       differ from those recognized for malnutrition or other pathological
       processes.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD  Amino Acids/*BLOOD
       Cystine/BLOOD  Human  *HIV-1  Leukocyte Count  Lysine/BLOOD
       Methionine/BLOOD  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Taurine/BLOOD  Tryptophan/BLOOD  T4 Lymphocytes/PATHOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).