Document 0004
 DOCN  M9470004
 TI    Induction of apoptosis in a T lymphoblastoid cell line infected with
       feline immunodeficiency virus.
 DT    9409
 AU    Ohno K; Okamoto Y; Miyazawa T; Mikami T; Watari T; Goitsuka R; Tsujimoto
       H; Hasegawa A; Department of Veterinary Internal Medicine, Faculty of;
       Agriculture, University of Tokyo, Japan.
 SO    Arch Virol. 1994;135(1-2):153-8. Unique Identifier : AIDSLINE
       MED/94256834
 AB    The mechanism of cell death induced by feline immunodeficiency virus
       (FIV) infection was investigated in an interleukin 2(IL-2)-dependent
       T-lymphoblastoid cell line (MYA-1). DNA extracted from FIV-infected
       MYA-1 cells showed a ladder of nucleosomal DNA, indicating that the
       cytopathic effect (CPE) observed in these cells was due to apoptosis.
       Infection of MYA-1 cells with FIV was associated with suppression of the
       proliferative response of the cells to exogenous IL-2 prior to DNA
       fragmentation. These findings suggest that FIV-induced CPE in these
       T-lymphoblastoid cells is associated with apoptosis possibly due to a
       defect in the IL-2 signal transduction pathway.
 DE    Animal  *Apoptosis  Cats  Cell Division/DRUG EFFECTS  Cell Line  DNA
       Damage  Flow Cytometry  Human  Immunodeficiency Virus,
       Feline/*PHYSIOLOGY/PATHOGENICITY  Interleukin-2/PHARMACOLOGY  Receptors,
       Interleukin-2/*BIOSYNTHESIS  Recombinant Proteins/PHARMACOLOGY
       T-Lymphocytes/*CYTOLOGY/MICROBIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).