Document 0005
 DOCN  M9470005
 TI    Human cytomegalovirus replication correlates with differentiation in a
       hematopoietic progenitor cell line and can be modulated by HIV-1.
 DT    9409
 AU    Lazzarotto T; Furlini G; Re MC; Ramazzotti E; Campisi B; Landini MP;
       Institute of Microbiology, University of Bologna, Italy.
 SO    Arch Virol. 1994;135(1-2):13-28. Unique Identifier : AIDSLINE
       MED/94256831
 AB    Human cytomegalovirus (HCMV) infection of a CD34+ hematopoietic
       progenitor cell line (TF1) was studied before and after TPA
       differentiation. TF1 cells were found to be infected but the virus does
       not replicate, while differentiated TF1 cells can be infected and allow
       HCMV complete replication. In the same system we studied the interaction
       between HCMV and HIV and found that while contact between HIV gp 120 and
       the HCMV-infected cell has an inhibitory effect, exogenous Tat protein
       stimulates HCMV replication. The interaction between HCMV and HIV in
       hematopoietic progenitor cells is complex and depends on several factors
       that can have opposite effects.
 DE    Antigens, CD/ANALYSIS  Antigens, Viral/ANALYSIS  *Cell
       Differentiation/DRUG EFFECTS  Cell Line
       Cytomegalovirus/GENETICS/*PHYSIOLOGY  DNA, Viral/ANALYSIS  Fluorescent
       Antibody Technique  Gene Products, tat/METABOLISM  Genome, Viral
       Hematopoietic Stem Cells  Human  HIV Core Protein p24/ANALYSIS  HIV
       Envelope Protein gp120/METABOLISM  HIV-1/GENETICS/*PHYSIOLOGY  Kinetics
       Polymerase Chain Reaction  Recombinant Proteins/METABOLISM  Support,
       Non-U.S. Gov't  Tetradecanoylphorbol Acetate/PHARMACOLOGY  *Virus
       Replication  JOURNAL ARTICLE

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