Document 0015
 DOCN  M9470015
 TI    Intestinal permeability in patients infected with the human
       immunodeficiency virus.
 DT    9409
 AU    Tepper RE; Simon D; Brandt LJ; Nutovits R; Lee MJ; Division of
       Gastroenterology, Bronx Municipal Hospital Center,; New York.
 SO    Am J Gastroenterol. 1994 Jun;89(6):878-82. Unique Identifier : AIDSLINE
       MED/94256460
 AB    OBJECTIVE: The etiology of acquired immunodeficiency syndrome (AIDS)
       enteropathy is unknown. This condition has been associated with
       malabsorption and villous atrophy. Other disorders with similar
       findings, including celiac disease, are characterized by altered
       intestinal permeability. Our objective was to confirm (or reject) our
       hypothesis that processes that cause increased permeability may occur in
       patients with AIDS, and thus be a cause of idiopathic diarrhea. METHODS:
       A lactulose-mannitol differential intestinal permeability test was
       performed in healthy controls, asymptomatic human immunodeficiency virus
       (HIV)-positive patients, and AIDS patients with and without diarrhea.
       RESULTS: Asymptomatic HIV-positive patients lactulose and mannitol
       recoveries were no different than healthy control patients. AIDS
       patients without diarrhea had lactulose recovery similar to healthy
       controls and decreased mannitol recoveries; their mean
       lactulose:mannitol ratio was no different from that of controls, and
       less than that of AIDS patients with diarrhea. AIDS patients with
       diarrhea had increased lactulose recovery and decreased mannitol
       recovery; their mean lactulose:mannitol ratio was significantly greater
       than the ratios in all the other groups. CONCLUSIONS: Patients with AIDS
       and diarrhea have altered intestinal permeability. The decreased
       absorption of mannitol suggests that the functional absorptive surface
       of the intestine decreases as HIV disease progresses.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PHYSIOPATHOLOGY  Adult
       AIDS-Related Opportunistic Infections/PHYSIOPATHOLOGY
       Diarrhea/COMPLICATIONS/PHYSIOPATHOLOGY  Human  HIV
       Seropositivity/PHYSIOPATHOLOGY  Intestines/*PHYSIOPATHOLOGY
       Lactulose/METABOLISM  Mannitol/METABOLISM  Middle Age  Permeability
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).