Document 0023
 DOCN  M9470023
 TI    [Bone marrow granulomas]
 DT    9409
 AU    Vijnovich Baron IA; Barazzutti L; Tartas N; Korin J; Sanchez Avalos JC;
       Departamento de Patologiay Citologia, Sanatorio Guemes, Buenos; Aires,
       Argentina.
 SO    Sangre (Barc). 1994 Feb;39(1):35-8. Unique Identifier : AIDSLINE
       MED/94255831
 AB    PURPOSE: To evaluate bone marrow granulomatous lesions in order to
       establish their etiology. MATERIAL AND METHODS: 2,250 bone marrow
       biopsies were studied during the period of March 1983-March 1991.
       Granulomas and/or granulomatous lesions were found in 24 of them
       (1.06%). A correlation between histological characteristics, special
       stains: PAS, Ziehl Neelsen and Grocott and cultures were done.
       Immunohistochemistry was done to evaluate B or T cell-lineage in 4
       patients. RESULTS: The 24 patients were biopsied because of the clinical
       diagnosis of haematological and non-haematological neoplasias,
       infections, AIDS, sarcoidosis and fever of unknown origin. Bone marrow
       cellularity ranged from 20% to 75% (M: 49.8%). Myeloid cells were
       increased in 54% of the cases. The number of granulomas ranged from 1 to
       19 (M: 3.9). The epithelioid cells were the predominant component in 66%
       of the cases. Of the 7 patients with non-Hodgkin's lymphoma, 4 had
       lymphomatous involvement with granulomatous pattern. These cases showed
       predominance of lymphoid cells and vessels in addition to epithelioid
       cells. CONCLUSION: We consider that in order to establish a relationship
       between infection and granuloma, the identification of a microorganism
       through a culture is a more reliable test. We couldn't find any
       morphological characteristic which allowed an etiologic diagnosis of
       bone marrow granulomas. In case of lesions with a great lymphocytic and
       vascular proliferation plus the presence of epithelioid cells and
       fibrosis, NHL with bone marrow involvement with a granulomatous pattern
       should be strongly considered.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Adolescence  Adult
       Aged  Aged, 80 and over  Argentina/EPIDEMIOLOGY  Bone Marrow
       Diseases/*EPIDEMIOLOGY/ETIOLOGY/MICROBIOLOGY/  PATHOLOGY/PARASITOLOGY
       Bone Marrow Examination  Cryptococcosis/EPIDEMIOLOGY/PATHOLOGY  English
       Abstract  Female  Fever of Unknown Origin/COMPLICATIONS
       Granuloma/*EPIDEMIOLOGY/ETIOLOGY/MICROBIOLOGY/PATHOLOGY/  PARASITOLOGY
       Histoplasmosis/EPIDEMIOLOGY/PATHOLOGY  Human  Ilium  Incidence
       Lymphoma, Non-Hodgkin's/COMPLICATIONS  Male  Middle Age
       Tuberculoma/EPIDEMIOLOGY/PATHOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       MULTICASE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).