Document 0024
 DOCN  M9470024
 TI    [HIV and blood donors: past, present and future]
 DT    9409
 AU    Leon de Gonzalez G; Hernandez T; Arias F; Celis S; Acosta V; Semprun O;
       Lugo de Moron M; Banco Municipal de Sangre del D.F. Servicio de;
       Inmunohematologia, San Jose Caracas, Venezuela.
 SO    Sangre (Barc). 1994 Feb;39(1):15-21. Unique Identifier : AIDSLINE
       MED/94255827
 AB    PURPOSE: To evaluate the changes in the spectrum of HIV-positive blood
       donors along seven years. PATIENTS AND METHODS: The municipal Blood Bank
       of Caracas Federal District examined 193,796 blood donors between 1986
       and 1992. Anti-HIV antibodies were determined by the following methods:
       Ortho HIV-Elisa Test System (59.5% of the samples), Abbott Recombinant
       HIV-EIA (28.6%), Vironostika HIV Microelisa System-Organon Teknika
       (2.1%), Bio-Test anti-HIV Recombinant Elisa (2.1%), and Recombigen (env
       and gag) HIV Cambridge Biotech (7.7%). Results confirmation was
       performed with Biotech/Dupont HIV-I Western Blot Kit, Chiron Riba HIV
       216 Test System and Inno-Lia HIV 1/2 Ab immunogenetics SA. RESULTS: Slow
       but progressive increase of positive results was seen in the blood
       donors along the years, from 0.05% in 1986 to 0.31% in 1992. Higher
       prevalence was seen in males (p < 0.001), although absolute increase in
       the number of positive females was found by 1992 (p < 0.05). According
       to their type, 80.6% of the donors were patient-related (RD), 13%
       attended mobile blood-drawing units (MU) and 6.4% were VD (p < 0.001),
       with a trend to increase amongst DR and decrease amongst MV. The
       majority of the positive donors pertained to homo-or bisexuals (60.5%),
       although they showed progressive decrease, whereas the positive findings
       increased in the promiscuous heterosexual group and amongst those having
       contacts with persons at risk. CONCLUSIONS: High prevalence of
       HIV-positive donors is found, the expected figure for 1995 being 0.37%
       if the present trends are maintained. Thus, a better selection of blood
       donors is recommended by means of careful enquiries, the use of optimal
       reagents capable of shortening the window period, deferring people at
       risk from blood donation, and promoting altruistic voluntary donation of
       blood.
 DE    Adolescence  Adult  *Blood Donors  English Abstract  Female  Human  HIV
       Antibodies/*BLOOD  HIV Seropositivity/*EPIDEMIOLOGY  HIV
       Seroprevalence/*TRENDS  *HIV-1  *HIV-2  Male  Middle Age  Risk Factors
       Venezuela/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).