Document 0033
 DOCN  M9470033
 TI    [Antimalarial 10 H-indolo(3,2-b)quinolin-11-yl-amines. 1.
       Phenol-Mannich-bases of the amodiaquine and cycloquine type.
 DT    9409
 AU    Gorlitzer K; Stockmann R; Walter RD; Institut fur Pharmazeutische
       Chemie, Technischen Universitat; Braunschweig.
 SO    Pharmazie. 1994 Apr;49(4):231-5. Unique Identifier : AIDSLINE
       MED/94255521
 AB    The 11-chloro-quinoline derivatives 3 react with 4-aminophenol and the
       mono- and bis-phenol-Mannich-bases 6 to yield the
       10H-indolo[3,2-b]quinoline-11-yl-amines 4 and 7. The amodiaquine
       analogue 7a as the best of all compounds shows a comparable activity
       with choroquine and inhibits a multiresistant Plasmodium falciparum
       strain at the same concentration. Compound 7e from the cycloquine-type
       was selected for an in vivo antitumor screening programme.
 DE    Aminoquinolines/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Animal
       Antimalarials/*CHEMICAL SYNTHESIS/PHARMACOLOGY  Antiviral
       Agents/PHARMACOLOGY  Drug Resistance  Drug Screening Assays, Antitumor
       English Abstract  Human  HIV-1/DRUG EFFECTS  In Vitro  Indoles/*CHEMICAL
       SYNTHESIS/PHARMACOLOGY  Plasmodium falciparum/DRUG EFFECTS  JOURNAL
       ARTICLE

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