Document 0039
 DOCN  M9470039
 TI    Intravitreal use of foscarnet: retinotoxicity of repeated injections in
       the rabbit eye.
 DT    9409
 AU    Turrini B; Tognon MS; De Caro G; Secchi AG; Institute of Ophthalmology,
       University of Padua, School of; Medicine, Italy.
 SO    Ophthalmic Res. 1994;26(2):110-5. Unique Identifier : AIDSLINE
       MED/94255196
 AB    Cytomegalovirus retinitis is the most frequent ocular opportunistic
       infection in AIDS patients. In selected cases intravitreal injections of
       foscarnet may be the sole therapeutic possibility. The retinal toxicity
       of the drug, however, has not yet been thoroughly investigated. Our
       present study in the rabbit eye concerns the retinal toxicity of 2, 4,
       and 6 intravitreal injections of 3.6 mg of foscarnet, using
       ophthalmoscopy, histology and electrophysiology to evaluate retinal
       damage. The results show that foscarnet may be employed intravitreally
       without substantial damage to the retina, but only in short courses of
       injections when no other therapeutic possibility may be utilized.
 DE    Animal  Drug Administration Schedule  Electroretinography/DRUG EFFECTS
       Female  Foscarnet/ADMINISTRATION & DOSAGE/*TOXICITY  Fundus Oculi  Male
       Ophthalmoscopy  Rabbits  Retina/*DRUG EFFECTS/PATHOLOGY/PHYSIOPATHOLOGY
       Retinitis/CHEMICALLY INDUCED/PATHOLOGY/PHYSIOPATHOLOGY  Support,
       Non-U.S. Gov't  Vitreous Body  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).