Document 0066
 DOCN  M9470066
 TI    [Pathogenesis of Graves' disease]
 DT    9409
 AU    Yokoyama N; Nagataki S; First Department of Internal Medicine, Nagasaki
       University School; of Medicine.
 SO    Nippon Rinsho. 1994 Apr;52(4):1110-7. Unique Identifier : AIDSLINE
       MED/94254232
 AB    The discovery of long acting thyroid stimulator in Graves' disease and
       autoantibodies specific for the thyroid in Hashimoto disease in 1956,
       were the earliest examples of autoimmune responses. Autoimmune thyroid
       disease has many important advantages in the investigation of autoimmune
       disease when compared to the other disease. It is possible to obtain
       thyroid tissue at biopsy and to investigate the histology by various
       methods and the interactions between thyrocytes and infiltrated
       mononuclear cells in vitro. Important autoantigens, such as the TSH
       receptor, thyroid peroxidase and thyroglobulin have already been cloned
       and each autoantigen has a specific function. Furthermore, we can
       observe precisely the clinical course of the disease using laboratory
       parameters. In this review, the pathogenesis of Graves' disease will be
       overviewed using the results obtained, mainly in our laboratory, in the
       following topics: (1) Immunogenetics: HLA class I and II, Gm, multiple
       genes (2) Trigger: bacteria, retrovirus (HIV, HTLV-I), radiation (3)
       Initiation and perpetuation of autoimmune responses: role of HLA class I
       and II antigens, characteristics of infiltrated mononuclear cells,
       interactions among thyrocytes, mononuclear cells and endothelial cells,
       role of cytokines, adhesion molecules (4) Autoantibodies: methods of
       determination and clinical correlates of TSH receptor antibodies (5)
       Autoantigens: structure and functional relationship of TSH receptor (6)
       Future studies: possible methods of treatment based on pathogenesis, a
       model of new treatment.
 DE    Autoantibodies  Cell Adhesion Molecules  Cytokines  English Abstract
       Graves' Disease/*ETIOLOGY/GENETICS/IMMUNOLOGY  Human  HIV  HLA Antigens
       IgG  Radiation Injuries  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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