Document 0073
 DOCN  M9470073
 TI    Hyperperfusion and early technetium-99m-HMPAO SPECT appearance of
       central nervous system toxoplasmosis.
 DT    9409
 AU    Catafau AM; Sola M; Lomena FJ; Guelar A; Miro JM; Setoain J; Department
       of Nuclear Medicine, Hospital Clinic i Provincial,; University of
       Barcelona, Spain.
 SO    J Nucl Med. 1994 Jun;35(6):1041-3. Unique Identifier : AIDSLINE
       MED/94253901
 AB    Three correlative 99mTc-HMPAO brain SPECT studies were performed on an
       AIDS patient from the early stage of a CNS toxoplasma lesion to its
       resolution after specific therapy. A hyperactive area in the right
       parieto-occipital lobe appeared in the first SPECT study, matching the
       heterogeneous T2-weighted image with Gd-DTPA enhancement reported on
       MRI. Both studies were performed 3 days after the onset of neurological
       symptoms when no abnormalities were found on a CT scan. This fact can be
       explained by the hyperemia that occurs in the acute stage of
       inflammation. Three months later, along with clinical improvement under
       specific treatment, both MRI and brain SPECT were normal. No
       hypoperfusion was seen in SPECT images, probably because the necrotic
       phase of the toxoplasma lesion was not reached in this case.
 DE    Adult  AIDS-Related Opportunistic Infections/PHYSIOPATHOLOGY/
       *RADIONUCLIDE IMAGING  Brain/RADIONUCLIDE IMAGING  Case Report
       Cerebrovascular Circulation  Female  Human  Organotechnetium
       Compounds/*DIAGNOSTIC USE  Oximes/*DIAGNOSTIC USE  Support, Non-U.S.
       Gov't  *Tomography, Emission-Computed, Single-Photon  Toxoplasmosis,
       Cerebral/PHYSIOPATHOLOGY/*RADIONUCLIDE IMAGING  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).