Document 0074
 DOCN  M9470074
 TI    Pneumocystis carinii pneumonia presenting as focal bibasilar uptake on
       gallium scan during aerosolized pentamidine prophylaxis [see comments]
 DT    9409
 AU    Katial R; Honeycutt W; Oswald SG; Department of Medicine, Dwight D.
       Eisenhower Army Medical Center,; Fort Gordon, Georgia.
 SO    J Nucl Med. 1994 Jun;35(6):1038-40. Unique Identifier : AIDSLINE
       MED/94253900
 CM    Comment in: J Nucl Med 1994 Jun;35(6):1034-7
 AB    Radionuclide imaging with gallium is commonly performed in the
       evaluation of patients with suspected Pneumocystis carinii pneumonia
       (PCP) and is known to be highly sensitive for detection of PCP. We
       present a patient with acquired immunodeficiency who developed PCP in
       the bases of both lungs while on aerosolized pentamidine prophylaxis. A
       gallium scan demonstrated focal uptake in the lung bases, a pattern
       generally not associated with PCP, and was extremely useful in guiding
       bronchoscopy. An aerosol ventilation scan performed after complete
       resolution of the clinical illness demonstrated prominent ventilatory
       defects in the lung bases corresponding to the regions of previous
       gallium uptake. We speculate that the underlying ventilatory abnormality
       may have contributed to poor drug delivery to the lung bases.
       Pneumocystis carinii pneumonia must be considered with any focal area of
       gallium accumulation in patients receiving aerosolized pentamidine.
 DE    Adult  Aerosols  AIDS-Related Opportunistic Infections/PREVENTION &
       CONTROL/  *RADIONUCLIDE IMAGING  Case Report  Gallium
       Radioisotopes/*DIAGNOSTIC USE  Human  Lung/*RADIONUCLIDE IMAGING  Male
       Pentamidine/*ADMINISTRATION & DOSAGE  Pneumonia, Pneumocystis
       carinii/PREVENTION & CONTROL/  *RADIONUCLIDE IMAGING  JOURNAL ARTICLE

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